PMID: 9163545Apr 25, 1997Paper

Synaptic contacts between gonadotropin-releasing hormone-containing fibers and neurons in the suprachiasmatic nucleus and perichiasmatic area: an anatomical substrate for feedback regulation?

Brain Research
E M van der BeekR M Buijs

Abstract

The suprachiasmatic nucleus (SCN) is critically involved in the generation and entrainment of circadian rhythms in mammalian species. Both the occurrence and the timing of the luteinizing hormone surge on the afternoon of proestrus in the female rodent are critically dependent on the integrity of the SCN. Recently, we demonstrated the presence of a monosynaptic pathway from the SCN to the gonadotropin releasing hormone (GnRH) neurons in the preoptic area. In addition, we found that interaction between the SCN and the GnRH system may be found close to the SCN, since we observed apposition of SCN efferents and GnRH fibers at the ultrastructural level in that region. The aim of the present study was to investigate the presence of synaptic contacts between GnRH fibers and structures in the SCN and surrounding perichiasmatic area (periSCN). At the light microscopical level, the immunoreactivity for GnRH showed a considerable overlap with the immunoreactivity for vasopressin and vasoactive intestinal peptide, two neuropeptides synthesized by SCN neurons. At the ultrastructural level, we demonstrated synaptic input of GnRH-containing axons on immunocytochemically unidentified structures in the SCN/peri-SCN region. The present results ...Continue Reading

Citations

Dec 13, 2019·Reviews in Endocrine & Metabolic Disorders·Carlos-Camilo Silva, Roberto Domínguez
Aug 31, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Michael J Boden, David J Kennaway
Dec 31, 1997·The Journal of Comparative Neurology·M M Moga, R Y Moore
Dec 1, 2004·Human Reproduction Update·David J Kennaway
Apr 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·Toni R PakRobert J Handa
Mar 20, 2010·Endocrine Reviews·Catherine A Christian, Suzanne M Moenter
Nov 1, 2009·Integrative and Comparative Biology·Wilbur P WilliamsLance J Kriegsfeld
Mar 19, 2014·PloS One·Ling XiaoQun-Yong Zhou
Apr 5, 2001·The Journal of Nutritional Biochemistry·A R. Del Angel-MezaC Beas-Zárate
Feb 25, 2006·Hormones and Behavior·Lance J Kriegsfeld, Rae Silver

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