PMID: 6539712Jul 1, 1984Paper

Synaptic density in chronic animals with experimental neurofibrillary changes

Experimental Neurology
E Uemura, W P Ireland

Abstract

Synaptic density was quantitated in the cerebral cortex and subiculum of rabbits with experimental neurofibrillary changes. Animals were subjected to subcutaneous injection of aluminum tartrate for 90 days, and synapses stained with ethanolic phosphotungstic acid were analyzed in animals killed 100, 200, or 300 days postinjection with aluminum tartrate. A significant difference was found in synaptic density between animals injected with aluminum tartrate and their age-matched controls. This difference was a result of a low synaptic density present in animals killed 200 or 300 days postinjection of aluminum tartrate. In contrast, animals killed 100 days postinjection revealed the same synaptic density as their control. The data suggest that the synaptic depopulation associated with experimental neurofibrillary changes is a gradual process, and such changes are demonstrable only long after the initial appearance of neurofibrillary changes.

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Citations

Mar 1, 1990·Environmental Geochemistry and Health·D R Crapper McLachlanT P Kruck
Jan 1, 1993·Progress in Neurobiology·H MeiriA Rousseau
Sep 1, 1986·Neurochemical Research·M F VanBerkumD R Crapper McLachlan
Sep 1, 1985·Experimental Neurology·E UemuraR E Bowman
Jan 1, 1987·Critical Reviews in Clinical Laboratory Sciences·R L Bertholf
Aug 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M J Strong, R M Garruto
Aug 7, 2007·Journal of Inorganic Biochemistry·Paula P Gonçalves, Virgília S Silva

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