Synaptic Failure: Focus in an Integrative View of ALS

Brain Plasticity
Caty CasasDora Brites

Abstract

From early description by Charcot, the classification of the Amyotrophic Lateral Sclerosis (ALS) is evolving from a subtype of Motor Neuron (MN) Disease to be considered rather a multi-systemic, non-cell autonomous and complex neurodegenerative disease. In the last decade, the huge amount of knowledge acquired has shed new insights on the pathological mechanisms underlying ALS from different perspectives. However, a whole vision on the multiple dysfunctional pathways is needed with the inclusion of information often excluded in other published revisions. We propose an integrative view of ALS pathology, although centered on the synaptic failure as a converging and crucial player to the etiology of the disease. Homeostasis of input and output synaptic activity of MNs has been proved to be severely and early disrupted and to definitively contribute to microcircuitry alterations at the spinal cord. Several cells play roles in synaptic communication across the MNs network system such as interneurons, astrocytes, microglia, Schwann and skeletal muscle cells. Microglia are described as highly dynamic surveying cells of the nervous system but also as determinant contributors to the synaptic plasticity linked to neuronal activity. Sever...Continue Reading

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Citations

Mar 29, 2019·International Journal of Molecular Sciences·Rosario GulinoRosalba Parenti
Mar 4, 2020·International Journal of Molecular Sciences·Keisuke HitachiKunihiro Tsuchida
Mar 18, 2020·International Journal of Molecular Sciences·Antonio M G de DiegoAntonio G García
Nov 5, 2019·Frontiers in Cellular Neuroscience·Fiona LimanaqiFrancesco Fornai
Mar 7, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dario RicciardiGiovanni Cirillo
Apr 4, 2021·International Journal of Molecular Sciences·Keisuke HitachiKunihiro Tsuchida
Jan 1, 2021·Journal of Neurochemistry·Rianne de JonghR Jeroen Pasterkamp
Jul 13, 2021·Frontiers in Cellular Neuroscience·Andres Di PaoloJosé Roberto Sotelo-Silveira
Aug 14, 2021·European Journal of Medicinal Chemistry·Olmo Martín-CámaraJ Carlos Menéndez
Nov 16, 2021·Frontiers in Cell and Developmental Biology·Zachary FralishNenad Bursac

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Methods Mentioned

BETA
transgenic
biopsies

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