Synaptic function and plasticity in identified inhibitory inputs onto VTA dopamine neurons

The European Journal of Neuroscience
Abigail M PolterJulie A Kauer

Abstract

Ventral tegmental area (VTA) dopaminergic neurons are key components of the reward pathway, and their activity is powerfully controlled by a diverse array of inhibitory GABAergic inputs. Two major sources of GABAergic nerve terminals within the VTA are local VTA interneurons and neurons in the rostromedial tegmental nucleus (RMTg). Here, using optogenetics, we compared synaptic properties of GABAergic synapses on VTA dopamine neurons using selective activation of afferents that originate from these two cell populations. We found little evidence of co-release of glutamate from either input, but RMTg-originating synaptic currents were reduced by strychnine, suggesting co-release of glycine and GABA. VTA-originating synapses displayed a lower initial release probability, and at higher frequency stimulation, short-term depression was more marked in VTA- but not RMTg-originating synapses. We previously reported that nitric oxide (NO)-induced potentiation of GABAergic synapses on VTA dopaminergic cells is lost after exposure to drugs of abuse or acute stress; in these experiments, multiple GABAergic afferents were simultaneously activated by electrical stimulation. Here we found that optogenetically-activated VTA-originating synapses...Continue Reading

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Citations

May 8, 2018·The European Journal of Neuroscience·Salma A Quraishi, Carlos A Paladini
Jul 2, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yannick FotioRoberto Ciccocioppo
Jan 30, 2020·International Journal of Molecular Sciences·Maria Carolina Velasquez-MartinezCarlos A Jimenez-Rivera
Dec 24, 2019·Frontiers in Neural Circuits·Chloé BouarabAbigail M Polter
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Ryan D Shepard, Fereshteh S Nugent
Jan 22, 2021·Pharmacology & Therapeutics·Nuria Morales-PuertoMaría Isabel Colado
Apr 10, 2021·Behavioural Brain Research·Andrea K ShieldsCaroline E Bass
Aug 29, 2018·Trends in Neurosciences·Alexey Ostroumov, John A Dani

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