Synaptic Impairment in Alzheimer's Disease: A Dysregulated Symphony

Trends in Neurosciences
Stefania FornerFrank M LaFerla

Abstract

Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and devastating neurodegeneration, not only as a result of the extracellular accumulation of beta-amyloid peptide (Aβ) and intracellular accumulation of tau, but also as a consequence of the dysfunction and loss of synapses. Although significant advances have been made in our understanding of the relationship of the pathological role of Aβ and tau in synapse dysfunction, several questions remain as to how Aβ and tau interdependently cause impairments in synaptic function in AD. Overall, more insight into these questions should enable researchers in this field to develop novel therapeutic targets to mitigate or delay the cognitive deficits associated with this devastating disease.

References

Apr 2, 2010·Nature·Alix de CalignonBradley T Hyman
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erik D RobersonLennart Mucke
Apr 8, 2011·Science Translational Medicine·David M HoltzmanAlison M Goate
Jun 8, 2011·Molecular Neurodegeneration·Cristian A Lasagna-ReevesRakez Kayed
Jul 19, 2011·Biochemical Pharmacology·H Rheinallt ParriKelly T Dineley
Sep 15, 2011·Neurobiology of Learning and Memory·Sergio T Ferreira, William L Klein
Oct 12, 2011·The FEBS Journal·Catherine H TrepanierJohn F MacDonald
Nov 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masashi KitazawaFrank M LaFerla
Nov 30, 2011·Journal of Neurochemistry·Megan E Larson, Sylvain E Lesné
Jan 6, 2012·Nature Reviews. Neuroscience·Zu-Hang Sheng, Qian Cai
Jan 19, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cristian A Lasagna-ReevesRakez Kayed
Jan 31, 2012·Neurobiology of Aging·Daniela PuzzoAgostino Palmeri
Mar 20, 2012·Molecular Neurodegeneration·Katherine L YoumansMary Jo LaDu
May 29, 2012·Brain : a Journal of Neurology·Robert M KoffieTara L Spires-Jones
May 29, 2012·Neurochemical Research·David Heras-SandovalClorinda Arias
Jun 13, 2012·The American Journal of Pathology·Rodrigo MedeirosFrank M LaFerla
Jul 27, 2012·The Journal of Biological Chemistry·Siddhartha Mondragón-RodríguezJannic Boehm
Oct 3, 2012·Translational Neuroscience·Katherine J KopeikinaTara L Spires-Jones
Oct 11, 2012·Scientific Reports·Cristian A Lasagna-ReevesRakez Kayed
Nov 7, 2012·The Journal of Biological Chemistry·Katharina FlachMax Holzer
Nov 20, 2012·Archives of Medical Research·Ana Luisa Sosa-OrtizMartin J Prince
Nov 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Megan LarsonSylvain E Lesné
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Meredith A ChabrierFrank M LaFerla
Feb 14, 2013·Neurobiology of Aging·Jasmine RamcharitarAndrea C LeBlanc
Apr 12, 2013·Brain : a Journal of Neurology·Sylvain E LesnéKaren H Ashe
May 4, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuko TakedaBradley T Hyman
Jun 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cláudia P FigueiredoSergio T Ferreira
Jun 19, 2013·Frontiers in Neurology·Jürgen GötzHannah Nicholas
Jul 12, 2013·PloS One·Adrianna Z HerskovitsBradley T Hyman
Jul 13, 2013·Frontiers in Aging Neuroscience·Kathleen R Zahs, Karen H Ashe
Oct 1, 2013·Neuropharmacology·Amy M PoolerDiane P Hanger
Nov 13, 2013·Nature Reviews. Neurology·Ezio Giacobini, Gabriel Gold
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tetsuya KimuraKwangwook Cho
Dec 18, 2013·Brain Research Bulletin·J Nicholas CochranErik D Roberson
Jan 28, 2014·Biochemical Pharmacology·Miguel Medina, Jesús Avila
Feb 15, 2014·Human Molecular Genetics·Christina R MuratoreTracy L Young-Pearse
Mar 5, 2014·Annals of Neurology·Roberta RicciarelliErnesto Fedele

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Citations

Aug 3, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jong Kil Lee, Nam-Jung Kim
Jan 13, 2018·Frontiers in Neurology·Peter N AlexandrovWalter J Lukiw
Mar 6, 2018·Journal of Alzheimer's Disease : JAD·Alessandra C MartiniFrank M LaFerla
Jan 17, 2019·Molecular Neurobiology·Siqi ZhaoShuang Rong
Feb 22, 2018·Current Environmental Health Reports·Kimberly C PaulBeate Ritz
Feb 28, 2019·Aging Cell·Laura Trujillo-EstradaFrank M LaFerla
Nov 27, 2018·The Journal of Endocrinology·Lenka MaletínskáJaroslav Kuneš
Apr 11, 2018·Molecular Neurobiology·Yuhai Zhao, Walter J Lukiw
Aug 11, 2019·Molecular Neurobiology·María F Zappa VillarPaula C Reggiani
Nov 14, 2019·Cellular and Molecular Neurobiology·Mu-Wen ChenYu Qiu
Oct 2, 2019·International Journal of Molecular Sciences·Song XueZheng Zheng
Dec 4, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·S Scott SuttonJames W Hardin
May 17, 2019·Alzheimer's Research & Therapy·Dolores Siedlecki-WullichAlfredo J Miñano-Molina
Sep 1, 2017·Translational Neurodegeneration·Brati Das, Riqiang Yan
Jul 16, 2020·The Journal of Pharmacy and Pharmacology·Fanxing XuZhenzhong Wang
Aug 1, 2020·Frontiers in Cell and Developmental Biology·Elena V MitroshinaMaria V Vedunova
Sep 1, 2017·Scientific Reports·David Baglietto-VargasAntonia Gutierrez
May 11, 2018·Oxidative Medicine and Cellular Longevity·Md JakariaDong-Kug Choi
Feb 19, 2019·Journal of Alzheimer's Disease : JAD·Hui XiaUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 28, 2019·The Journal of Biological Chemistry·Yuxing XiaBenoit I Giasson
Mar 22, 2020·Journal of Neuroinflammation·Maralinde R AbbinkAniko Korosi
Apr 9, 2020·Frontiers in Cellular Neuroscience·Carolina Flores-MuñozÁlvaro O Ardiles
Aug 12, 2018·International Journal of Molecular Sciences·Yu-Chia KaoKuen-Jer Tsai
Nov 13, 2018·Frontiers in Systems Neuroscience·Jesse J Langille, Richard E Brown
Aug 15, 2018·Molecular Neurobiology·Fernando DobrachinskiFélix A A Soares
Feb 6, 2019·Scientific Reports·Alina C StimmellAaron A Wilber
May 17, 2019·Expert Opinion on Investigational Drugs·Justin L HoskinBoris Decourt
Jan 24, 2020·Frontiers in Aging Neuroscience·Miren EttchetoAntonio Camins
Feb 24, 2020·GeroScience·Yin ZhaoXin A Zhang

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