Synaptic Innervation of the GnRH Neuron Distal Dendron in Female Mice

Endocrinology
Aleisha M MooreAllan E Herbison

Abstract

GnRH neuron cell bodies are scattered throughout the basal forebrain but funnel their projections to the median eminence to release GnRH into the pituitary portal system to control fertility. Prior studies have shown that GnRH neurons located in the anterior hypothalamus send projections to the median eminence that have characteristics of both dendrites and axons. These unusual structures have been termed "dendrons." To address whether the dendron is unique to anterior hypothalamic GnRH neurons or is also a characteristic of more rostral GnRH neurons, we used viral vector‒mediated GnRH neuron‒specific tract-tracing coupled with CLARITY optical clearing. Individual rostral preoptic area GnRH neurons in female mice were identified to elaborate processes up to 4 mm in length that exhibited spines and projected all the way to the median eminence before branching into multiple short axons. The synaptic innervation patterns of distal GnRH neuron dendrons and their short axons in the vicinity of the median eminence were examined using electron microscopy. This revealed the presence of a high density of synaptic inputs to distal dendrons at the border of the median eminence. In contrast, no synapses were detected on any GnRH neuron axo...Continue Reading

References

May 15, 1998·Neuron·J S Isaacson, B W Strowbridge
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Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karl J Iremonger, Allan E Herbison
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Jun 20, 2014·Nature Protocols·Raju TomerKarl Deisseroth
Oct 11, 2014·Neuroendocrinology·Karl J Iremonger, Allan E Herbison
Dec 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Pauline Campos, Allan E Herbison
Aug 2, 2015·Cell·Narayanan KasthuriJeff William Lichtman
Feb 27, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karl J IremongerAllan E Herbison
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Nov 8, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jenny ClarksonAllan E Herbison

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Citations

Oct 20, 2018·Endocrinology·Juan Roa, Manuel Tena-Sempere
Oct 3, 2018·Endocrinology·Allan E Herbison
Dec 13, 2019·Scientific Reports·Sarah HollandRebecca E Campbell
Dec 29, 2020·Endocrinology·Siew Hoong YipAllan E Herbison
Feb 6, 2021·Endocrinology·Siew Hoong YipAllan E Herbison
Aug 30, 2020·Molecular and Cellular Endocrinology·Kathryn B Smedlund, Jennifer W Hill
Jul 4, 2021·Journal of Neuroendocrinology·Aisha SatiRebecca E Campbell
Aug 25, 2021·Journal of Neuroendocrinology·Allan E Herbison
Dec 24, 2021·Journal of Neuroendocrinology·Stephanie ConstantinRichard Piet
Feb 3, 2022·Journal of Neuroendocrinology·Robert L GoodmanVictor M Navarro

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