Synaptic input from the retina to the suprachiasmatic nucleus changes with the light-dark cycle in the Syrian hamster

The Journal of Physiology
L N Cui, R E Dyball

Abstract

1. Single cell extracellular recordings were made from the suprachiasmatic nucleus (SCN) in urethane-anaesthetized Syrian hamsters at different times of the light-dark cycle. Peristimulus time histograms (PSTHs) were created following stimulation of the optic nerve. 2. Both short-latency (< 50 ms) and long-latency (> 50 ms) excitatory responses were seen. Almost all inhibitory responses had a short latency. 3. A total of 288 SCN neurones were recorded. Taking all types of response together, 55 (36.9%) of the 149 neurones tested in the dark period responded to optic nerve stimulation while only 23 (16.6%) of the 139 neurones tested in the light period responded. The difference between the proportion of all responsive and non-responsive neurones in the dark and light periods was highly significant (P < 0.01, Fisher's exact probability test). The difference in the proportion of excitatory responses was also significant (P < 0.01). 4. During the dark period, the mean spontaneous firing rate (5.00 +/- 0.88 spikes s-1; mean +/- S.E.M., n = 55) of the responsive cells was significantly higher than that of the non-responsive cells (2.65 +/- 0.33 spikes s-1; mean +/- S.E.M., n = 74; P < 0.01; Student's unpaired t test). 5. Injection of ...Continue Reading

Citations

Jun 10, 2000·Journal of Neuroendocrinology·K Saeb-ParsyR E Dyball
Jul 25, 2007·Progress in Neurobiology·Timothy M Brown, Hugh D Piggins
Oct 14, 2009·The European Journal of Neuroscience·Robert P Irwin, Charles N Allen
Sep 18, 2010·Journal of Neuroendocrinology·G S Bhumbra, R E J Dyball
Sep 10, 2014·The European Journal of Neuroscience·Hester C van DiepenTom Deboer
Nov 23, 2006·Brain Research Bulletin·Laurel L HaakEric M Mintz
Feb 24, 2015·Frontiers in Neuroendocrinology·Olivier BoslerAnne-Marie François-Bellan
Jun 28, 2003·Journal of Biological Rhythms·Johanna H Meijer, William J Schwartz
Apr 17, 2008·The European Journal of Neuroscience·G S BhumbraR E J Dyball
Sep 3, 2011·Nature Reviews. Neuroscience·Christopher S Colwell
Mar 13, 2020·Physiological Reviews·Jenna R M HarveyAndrea L Meredith
Aug 7, 2002·Journal of Neurophysiology·Stephan MichelChristopher S Colwell
Nov 23, 2020·Journal of Neurochemistry·Alan FlanaganJonathan D Johnston

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