Synaptic inputs and timing underlying the velocity tuning of direction-selective ganglion cells in rabbit retina.

The Journal of Physiology
Benjamin SivyerW Rowland Taylor

Abstract

There are two types of direction-selective ganglion cells (DSGCs) identified in the rabbit retina, which can be readily distinguished both morphologically and physiologically. The well characterized ON-OFF DSGCs respond to a broad range of image velocities whereas the less common ON DSGCs are tuned to slower image velocities. This study examined how the synaptic inputs shape the velocity tuning of DSGCs in an isolated preparation of the rabbit retina. The receptive-field properties were mapped by extracellular spike recordings and compared with the light-evoked excitatory and inhibitory synaptic conductances that were measured under voltage-clamp. The synaptic mechanisms underlying the generation of direction selectivity appear to be similar in both cell types in that preferred-direction image motion elicits a greater excitatory input and null-direction image motion elicits a greater inhibitory input. To examine the temporal tuning of the DSGCs, the cells were stimulated with either a grating drifted over the receptive-field centre at a range of velocities or with a light spot flickered at different temporal frequencies. Whereas the excitatory and inhibitory inputs to the ON-OFF DSGCs are relatively constant over a wide range o...Continue Reading

References

Feb 1, 1989·The Journal of Comparative Neurology·F R AmthorC W Oyster
Dec 1, 1988·Journal of Neurophysiology·J I SimpsonR E Soodak
Jul 1, 1974·The Journal of Physiology·B G Cleland, W R Levick
Sep 12, 1971·Documenta Ophthalmologica. Advances in Ophthalmology·C W OysterW R Levick
Dec 1, 1968·The Journal of Physiology·C W Oyster
Jun 1, 1965·The Journal of Physiology·H B Barlow, W R Levick
Feb 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D I Vaney
Jan 1, 1984·Annual Review of Neuroscience·J I Simpson
Jan 1, 1981·Vision Research·E V Famiglietti
Mar 1, 1980·The Journal of Comparative Neurology·C W OysterR E Soodak
Feb 1, 1997·Journal of Neurophysiology·C A Kittila, S C Massey
Dec 3, 2002·Nature·Shelley I FriedFrank S Werblin
Jan 16, 2003·The Journal of Comparative Neurology·Ramon F DacheuxFranklin R Amthor
Jul 10, 2003·Trends in Neurosciences·W Rowland Taylor, David I Vaney
Mar 17, 2004·The Journal of Comparative Neurology·Margaret A MacNeilRichard H Masland
Nov 27, 2004·The Journal of Physiology·Shijun WengShigang He
Sep 1, 2005·Neuron·Nicholas OeschW Rowland Taylor
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica M AckertStewart A Bloomfield
Aug 12, 2006·The Journal of Physiology·Wenzhi SunShigang He
Dec 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michiel van WykDavid I Vaney
Jul 5, 2008·Pflügers Archiv : European journal of physiology·Refik Kanjhan, David I Vaney
Jul 12, 2008·The Journal of Physiology·Z Jimmy Zhou, Seunghoon Lee
Feb 17, 2009·The Journal of Physiology·Gordon B Drummond
Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Benjamin SivyerDavid I Vaney

❮ Previous
Next ❯

Citations

Feb 9, 2012·Nature Reviews. Neuroscience·David I VaneyW Rowland Taylor
Apr 28, 2005·Developmental Neuroscience·Michael A ColicosMarla B Feller
Aug 30, 2011·Trends in Neurosciences·Wei Wei, Marla B Feller
May 17, 2014·Brain Research·Gergő CseteZsigmond Tamás Kincses
Apr 16, 2015·Visual Neuroscience·Aaron M HambyMarla B Feller
Sep 29, 2011·Neuron·Alexander Borst, Thomas Euler
Oct 15, 2013·Current Biology : CB·Melis Yilmaz, Markus Meister
May 11, 2016·Current Biology : CB·Rémi BosMarla B Feller
Aug 11, 2018·Annual Review of Vision Science·Wei Wei
Nov 24, 2015·Annual Review of Vision Science·Onkar S DhandeAndrew D Huberman
Jul 31, 2021·The Journal of Experimental Biology·Kristian Donner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.