Synaptic inputs to trigeminal primary afferent neurons cause firing and modulate intrinsic oscillatory activity

Journal of Neurophysiology
D VerdierA Kolta

Abstract

In this paper, we investigated the influence of synapses on the cell bodies of trigeminal muscle spindle afferents that lie in the trigeminal mesencephalic nucleus (NVmes), using intracellular recordings in brain stem slices of young rats. Three types of synaptic responses could be evoked by electrical stimulation of the adjacent supratrigeminal, motor, and main sensory nuclei and the intertrigeminal area: monophasic depolarizing postsynaptic potentials (PSPs), biphasic PSPs, and all or none action potentials without underlying excitatory PSPs (EPSPs). Many PSPs and spikes were abolished by bath-application of 6,7-dinitroquinoxaline (DNQX) alone or combined with D,L-2-amino-5-phosphonovaleric acid (APV), suggesting that they are mediated by non-N-methyl-D-aspartate (NMDA) and NMDA glutamatergic receptors, while some action potentials were sensitive to bicuculline, indicating involvement of GABAA receptors. A number of cells showed spontaneous membrane potential oscillations, and stimulation of synaptic inputs increased the amplitude of the oscillations for several cycles, which often triggered repetitive firing. Furthermore, the oscillatory rhythm was reset by the stimulation. Our results show that synaptic inputs to muscle pri...Continue Reading

References

Mar 15, 1978·The Journal of Comparative Neurology·J E Krettek, J L Price
Jan 1, 1991·Acta Anatomica·R S LiemJ D van Willigen
Apr 1, 1991·Journal of Neurophysiology·J P GossardS Rossignol
Apr 15, 1989·The Journal of Comparative Neurology·D Dessem, A Taylor
Jan 1, 1986·Acta Anatomica·J T RokxP J Jüch
Apr 1, 1987·Experimental Neurology·R Miyazaki, E S Luschei
Nov 1, 1970·Journal of Dental Research·C F Hinrichsen
Feb 15, 1970·The Japanese Journal of Physiology·M Takata, Y Kawamura
Mar 1, 1970·The American Journal of Anatomy·C F Hinrichsen, L M Larramendi
Jan 1, 1971·The Journal of Physiology·R Baker, R Llinás
Apr 4, 1997·Brain Research·A HayarK C Marshall
Jul 4, 1997·Neuroscience Letters·C Buisseret-DelmasP Buisseret

❮ Previous
Next ❯

Citations

Mar 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sebastian CurtiAlberto E Pereda
Feb 16, 2006·Archives of Histology and Cytology·Kohji IshihamaJack E Turman
Feb 22, 2012·Progress in Neurobiology·Philippe MorquetteArlette Kolta
Jul 6, 2010·Neuroscience Research·Takeshi TakahashiHiroyuki Nakamura
Oct 5, 2007·Brain Research Reviews·Nikolai E Lazarov
Nov 19, 2015·Frontiers in Cellular Neuroscience·Gemma Mazzuoli-Weber, Michael Schemann
Sep 22, 2011·The Journal of Comparative Neurology·Sang Kyoo PaikYong Chul Bae
Aug 4, 2006·Journal of Communication Disorders·James P Lund, Arlette Kolta
Mar 11, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jin-Eon HanIl-Sung Jang
Jul 29, 2017·Journal of Neuroscience Research·Akifumi EnomotoSuguru Hamada
Feb 21, 2018·Brain Structure & Function·Jin Young BaeYong Chul Bae
Jun 22, 2019·PLoS Computational Biology·Sharmila VenugopalScott H Chandler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.