Synaptic integrative mechanisms for spatial cognition

Nature Neuroscience
Christoph Schmidt-Hieber, Matthew F Nolan

Abstract

Synaptic integrative mechanisms have profound effects on electrical signaling in the brain that, although largely hidden from recording methods that observe the spiking activity of neurons, may be critical for the encoding, storage and retrieval of information. Here we review roles for synaptic integrative mechanisms in the selection, generation and plasticity of place and grid fields, and in related temporal codes for the representation of space. We outline outstanding questions and challenges in the testing of hypothesized models for spatial computation and memory.

References

Nov 1, 1978·Experimental Neurology·A J Hill
Apr 1, 1976·Experimental Neurology·J O'Keefe
Jul 1, 1991·Hippocampus·R U MullerR Saypoff
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Oct 1, 1996·Journal of Neurophysiology·R LipowskyC Alzheimer
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Oct 14, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J O'KeefeE A Maguire
Jun 9, 2000·Annual Review of Neuroscience·S J MartinR G Morris
Sep 14, 2000·Hippocampus·J J ChrobakG Buzsáki
Oct 29, 2000·Science·M HäusserG J Stuart
Mar 22, 2001·Nature Reviews. Neuroscience·J C Magee
Feb 8, 2002·Neuron·György Buzsáki
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Serena M Dudek, R Douglas Fields
Jul 19, 2002·Nature·Nace L GoldingNelson Spruston
Aug 27, 2002·Neuron·Neil BurgessJohn O'Keefe
Oct 10, 2002·Neural Networks : the Official Journal of the International Neural Network Society·Michael E HasselmoAnatoli Gorchetchnikov
Oct 22, 2002·Nature Neuroscience·Andrea LörinczZoltan Nusser
Dec 10, 2002·Annual Review of Physiology·Richard B Robinson, Steven A Siegelbaum
Jul 10, 2003·Current Opinion in Neurobiology·Michael Häusser, Bartlett Mel
Sep 3, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Loren M FrankEmery N Brown
Apr 27, 2005·Nature Neuroscience·Thu Jennifer Ngo-AnhJohn P Adelman
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sven MoosmangThomas Kleppisch

❮ Previous
Next ❯

Citations

Mar 21, 2019·Behavioral Sciences·Henk KoppelaarMartin van Warmerdam
Apr 3, 2019·Nature Biomedical Engineering·David L HuntMladen Barbic
Jun 11, 2020·Cell Reports·Benjamin J A RobertNathalie Sans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.