Synaptic maturation at cortical projections to the lateral amygdala in a mouse model of Rett syndrome.

PloS One
Frédéric GambinoYann Humeau

Abstract

Rett syndrome (RTT) is a neuro-developmental disorder caused by loss of function of Mecp2--methyl-CpG-binding protein 2--an epigenetic factor controlling DNA transcription. In mice, removal of Mecp2 in the forebrain recapitulates most of behavioral deficits found in global Mecp2 deficient mice, including amygdala-related hyper-anxiety and lack of social interaction, pointing a role of Mecp2 in emotional learning. Yet very little is known about the establishment and maintenance of synaptic function in the adult amygdala and the role of Mecp2 in these processes. Here, we performed a longitudinal examination of synaptic properties at excitatory projections to principal cells of the lateral nucleus of the amygdala (LA) in Mecp2 mutant mice and their wild-type littermates. We first show that during animal life, Cortico-LA projections switch from a tonic to a phasic mode, whereas Thalamo-LA synapses are phasic at all ages. In parallel, we observed a specific elimination of Cortico-LA synapses and a decrease in their ability of generating presynaptic long term potentiation. In absence of Mecp2, both synaptic maturation and synaptic elimination were exaggerated albeit still specific to cortical projections. Surprisingly, associative LT...Continue Reading

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Citations

Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Malik KhelfaouiYann Humeau
Jun 1, 2011·Neurobiology of Learning and Memory·Joanne Berger-Sweeney
Mar 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Wei LiLucas Pozzo-Miller
Aug 1, 2015·The Journal of Physiology·Daniel Bosch, Ingrid Ehrlich
Aug 3, 2013·Developmental Neurobiology·Grazia Della Sala, Tommaso Pizzorusso
Nov 10, 2010·Cellular and Molecular Neurobiology·M Zeniou-MeyerN Vitale
Aug 8, 2019·Autism Research : Official Journal of the International Society for Autism Research·Bo ZhangYongchang Chen
Jan 18, 2011·Experimental Biology and Medicine·Gaston CalfaLucas Pozzo-Miller

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