Synaptic mechanisms of interference in working memory

Scientific Reports
Zachary P Kilpatrick

Abstract

Information from preceding trials of cognitive tasks can bias performance in the current trial, a phenomenon referred to as interference. Subjects performing visual working memory tasks exhibit interference in their responses: the recalled target location is biased in the direction of the target presented on the previous trial. We present modeling work that develops a probabilistic inference model of this history-dependent bias, and links our probabilistic model to computations of a recurrent network wherein short-term facilitation accounts for the observed bias. Network connectivity is reshaped dynamically during each trial, generating predictions from prior trial observations. Applying timescale separation methods, we obtain a low-dimensional description of the trial-to-trial bias based on the history of target locations. Furthermore, we demonstrate task protocols for which our model with facilitation performs better than a model with static connectivity: repetitively presented targets are better retained in working memory than targets drawn from uncorrelated sequences.

References

Feb 1, 1989·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
Mar 1, 1995·Neuron·P S Goldman-Rakic
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·M V Tsodyks, H Markram
Jun 6, 1998·Neural Computation·M TsodyksH Markram
Sep 28, 1998·The European Journal of Neuroscience·C J PlonerC Pierrot-Deseilligny
Mar 26, 1999·Cognitive Psychology·B J Scholl, Z W Pylyshyn
Feb 27, 2001·Nature Neuroscience·C ConstantinidisP S Goldman-Rakic
Jun 21, 2001·Journal of Experimental Psychology. General·C LustigL Hasher
Jul 23, 2002·Nature Neuroscience·Bijan PesaranRichard A Andersen
Feb 19, 2005·Science·Christian K MachensCarlos D Brody
Sep 24, 2005·Experimental Brain Research·Simon J Bennett, Graham R Barnes
Dec 13, 2005·Neuroscience·J Jonides, D E Nee
Mar 21, 2006·Nature Neuroscience·Yun WangPatricia S Goldman-Rakic
Feb 27, 2007·PLoS Computational Biology·Omri Barak, Misha Tsodyks
Jun 30, 2007·Annual Review of Neuroscience·Joshua I Gold, Michael N Shadlen
Mar 8, 2008·Memory & Cognition·Tal Makovski, Yuhong V Jiang
Mar 15, 2008·Science·Gianluigi MongilloMisha Tsodyks
Apr 4, 2008·Nature·Weiwei Zhang, Steven J Luck
Apr 11, 2008·Nature Reviews. Neuroscience·Wickliffe C Abraham
May 20, 2008·Nature Neuroscience·Anne K ChurchlandMichael N Shadlen
Jul 24, 2008·PloS One·Joshua K Hartshorne
Aug 9, 2008·Science·Paul M Bays, Masud Husain
Dec 27, 2008·Neuron·Jeffrey M BeckAlexandre Pouget
Jul 7, 2009·Journal of Computational Neuroscience·Lawrence Christopher York, Mark C W van Rossum
Sep 26, 2009·Neuron·Joseph W Kable, Paul W Glimcher
Jun 24, 2010·Neural Computation·Robert C WilsonJoshua I Gold
Jul 16, 2010·Trends in Cognitive Sciences·Torkel Klingberg
Dec 4, 2010·Annual Review of Psychology·Gerd Gigerenzer, Wolfgang Gaissmaier
Oct 27, 2011·Frontiers in Computational Neuroscience·Vladimir ItskovMisha Tsodyks
Aug 17, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ziqiang WeiDa-Hui Wang
Oct 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yoram Burak, Ila R Fiete
Jan 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David Hansel, German Mato
Apr 9, 2013·Neuron·Mark G StokesJohn Duncan
Apr 25, 2013·PloS One·Edmund T RollsGustavo Deco
Jul 16, 2013·Trends in Cognitive Sciences·Steven J Luck, Edward K Vogel
Aug 21, 2013·Nature Neuroscience·Sukbin Lim, Mark S Goldman
Nov 19, 2013·PLoS Computational Biology·Martin BoerlinSophie Denève
Nov 26, 2013·Journal of Computational Neuroscience·Sam CarrollZachary P Kilpatrick

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Citations

Mar 19, 2019·PLoS Computational Biology·Paul C Bressloff
Apr 20, 2019·PLoS Computational Biology·Alexander SeeholzerWulfram Gerstner
Nov 28, 2019·Journal of Neurophysiology·Áine ByrneStephen Coombes
Jul 4, 2020·Scientific Reports·Joao Barbosa, Albert Compte
Sep 11, 2019·Physical Review. E·Paul C Bressloff, Samuel R Carroll
Jul 31, 2019·Nature Communications·Matthew F PanichelloTimothy J Buschman
Jan 6, 2021·PloS One·Nareg BerberianSylvain Chartier
Jan 6, 2021·Trends in Cognitive Sciences·Elizabeth S LorencJarrod A Lewis-Peacock

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