PMID: 1194931Dec 1, 1975Paper

Synaptic membrane structure in Torpedo electric organ

Journal of Neurocytology
J Rosenbluth

Abstract

The innervated and noninnervated membranes of Torpedo electrocytes have been examined by electron microscopy of thin-sectioned and freeze-fractured specimens. The ventral innervated membrane is approximately 120 A thick and is characterized by an unusually broad outer dense lamina (approximately 60 A) in which a granular substructure can be resolved. The granules are approximately 70 A in diameter and are spaced irregularly. The same membrane specialization was noted in a previous study of amphibian myoneural junctions, and it was proposed then that the granular elements represent ACh receptor molecules. The morphologically equivalent structures presumably have the same significance in the Torpedo electric organ. However, in this case the specialized membrane covers the entire innervated surface, leading to the conclusion that high concentrations of receptors occur normally in extrajunctional as well as post-junctional regions of the innervated membrane of the electrocyte. In replicas of freeze-fractured specimens, the A face of this membrane is covered with large particles having the same distribution and approximate concentration as the granules visible in thin sections, indicating that the granules visible at the outer surfa...Continue Reading

References

Jul 27, 1973·Brain Research·E Nickel, L T Potter
Mar 1, 1972·The Journal of Physiology·T Lomo, J Rosenthal
Jun 1, 1974·The Journal of Cell Biology·A L PolitoffG D Pappas
Mar 1, 1974·Journal of Neurocytology·J E HeuserD M Landis
Oct 1, 1973·The Journal of Cell Biology·J Rosenbluth
Oct 15, 1973·The Journal of Comparative Neurology·J Rosenbluth
Sep 29, 1970·Brain Research·E Nickel, L T Potter
Jan 1, 1965·The Journal of Cell Biology·M N SHERIDAN

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Citations

Jun 1, 1984·Cellular and Molecular Neurobiology·B MéndezN C Inestrosa
Jun 1, 1984·Journal of Neurocytology·S F Schaeffer
Jun 1, 1978·Journal of Neurocytology·S Tsuji
Apr 1, 1981·Journal of Neurocytology·B J McLaughlin, T S Reese
Feb 28, 1981·The Journal of Membrane Biology·P R Adams
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A G YeeM J Karnovsky
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E HoltzmanA Karlin
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A PerreletL Orgi
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y DunantA Parducz
Jun 1, 1989·The Journal of Cell Biology·S N AbramsonP Taylor
Jan 1, 1978·The Journal of Cell Biology·J Rosenbluth
Nov 1, 1978·Journal of Ultrastructure Research·M B Rheuben, T S Reese
May 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·F GrohovazR Miledi
Aug 15, 1978·The Journal of Comparative Neurology·R L GulleyT S Reese
Nov 1, 1993·The European Journal of Neuroscience·H BrasS Tyc-Dumont
Dec 1, 1991·Pacing and Clinical Electrophysiology : PACE·M Malik, A J Camm
May 25, 2006·Behavioral Neuroscience·Diana B PadlubnayaThomas H Brown
Nov 1, 1977·Journal of Molecular Biology·M J RossR M Stroud
Feb 15, 1977·The Journal of Comparative Neurology·R L Gulley, T S Reese
Sep 21, 1984·Science·J P ChangeuxP Chemouilli

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