PMID: 15374268Nov 1, 1994Paper

Synaptic mitochondria and ageing: computer-assisted morphometry in rat cerebellar glomeruli

Archives of Gerontology and Geriatrics
C Bertoni-FreddariW Meier-Ruge

Abstract

The ultrastructural features of synaptic mitochondria have been investigated by means of computer-assisted morphometry in the cerebellar glomeruli of young, adult and old rats. The volume fraction occupied by mitochondria (volume density: Vv), the number of organelles/ microm(3) (numerical density: Nv), the average volume (V) and the average length (Sk) of the mitochondria were the parameters measured in electron microscopic photos taken at an enlargement of x 8000. Vv showed a lifespan constancy. Nv was increased in the adult group vs. the young, but it was decreased in old animals as compared with the other 2 groups of age studied. V and Sk showed the same age-dependent changes: a significant decrease in the adults and a significant increase in the old rats vs. the other groups analysed, respectively. We interpret these findings to represent age-dependent morphofunctional adaptations occurring at synaptic mitochondria as a response to actual energy demands from the synaptic connectivity they subserve. Although impaired, the dynamic morphology of synaptic mitochondria appears to be capable of consistent compensative ultrastructural rearrangements in the central nervous system of old individuals.

References

Jun 1, 1992·Pathology, Research and Practice·C Bertoni-FreddariJ Ulrich
Sep 1, 1990·Brain Research. Brain Research Reviews·R K Calverley, D G Jones
Jan 1, 1990·Neurobiology of Aging·S W ScheffD A Price
Oct 1, 1985·Archives of Gerontology and Geriatrics·S Hoyer
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R K Carlin, P Siekevitz
Jan 1, 1983·Neurobiology of Aging·C A Curcio, J W Hinds
Jul 22, 1993·Annals of the New York Academy of Sciences·G L Kovács, D H Versteeg

❮ Previous
Next ❯

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.