Synaptic patterning of left-right alternation in a computational model of the rodent hindlimb central pattern generator.

Journal of Computational Neuroscience
William Erik SherwoodJohn Guckenheimer

Abstract

Establishing, maintaining, and modifying the phase relationships between extensor and flexor muscle groups is essential for central pattern generators in the spinal cord to coordinate the hindlimbs well enough to produce the basic walking rhythm. This paper investigates a simplified computational model for the spinal hindlimb central pattern generator (CPG) that is abstracted from experimental data from the rodent spinal cord. This model produces locomotor-like activity with appropriate phase relationships in which right and left muscle groups alternate while extensor and flexor muscle groups alternate. Convergence to this locomotor pattern is slow, however, and the range of parameter values for which the model produces appropriate output is relatively narrow. We examine these aspects of the model's coordination of left-right activity through investigation of successively more complicated subnetworks, focusing on the role of the synaptic architecture in shaping motoneuron phasing. We find unexpected sensitivity in the phase response properties of individual neurons in response to stimulation and a need for high levels of both inhibition and excitation to achieve the walking rhythm. In the absence of cross-cord excitation, equal...Continue Reading

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Citations

Oct 19, 2012·Journal of Neurophysiology·Michael S CarrollJan-Marino Ramirez
Oct 19, 2012·Journal of Neurophysiology·Guoji Wu, Steve I Perlmutter
Mar 24, 2012·Journal of Neurophysiology·Jason DyckSimon Gosgnach
Apr 18, 2014·PloS One·Jeremy WojcikAndrey L Shilnikov
Apr 2, 2013·Journal of Neuroscience Methods·Andrew J SpenceRachel Lampe
Oct 4, 2016·Frontiers in Human Neuroscience·Yushin KimDiane L Damiano
Jan 8, 2016·Journal of Mathematical Neuroscience·Peter AshwinRachel Nicks
Sep 1, 2017·Journal of Neurophysiology·Lea Ziskind-Conhaim, Shawn Hochman
Oct 6, 2017·Journal of Neurophysiology·Jessica AusbornJonathan E Rubin
Jan 12, 2021·Frontiers in Neural Circuits·Natalia A ShevtsovaKimberly J Dougherty
Feb 13, 2021·International Journal of Molecular Sciences·Vladimir Rancic, Simon Gosgnach
Jul 3, 2021·International Journal of Molecular Sciences·Jessica AusbornSimon M Danner

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