Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories

Neuron
Marco BocchioMarco Capogna

Abstract

The neuronal circuits of the basolateral amygdala (BLA) are crucial for acquisition, consolidation, retrieval, and extinction of associative emotional memories. Synaptic plasticity in BLA neurons is essential for associative emotional learning and is a candidate mechanism through which subsets of BLA neurons (commonly termed "engram") are recruited during learning and reactivated during memory retrieval. In parallel, synchronous oscillations in the theta and gamma bands between the BLA and interconnected structures have been shown to occur during consolidation and retrieval of emotional memories. Understanding how these cellular and network phenomena interact is vital to decipher the roles of emotional memory formation and storage in the healthy and pathological brain. Here, we review data on synaptic plasticity, engrams, and network oscillations in the rodent BLA. We explore mechanisms through which synaptic plasticity, engrams, and long-range synchrony might be interconnected.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S M Dudek, M F Bear
Jul 29, 1994·Science·M A Wilson, B L McNaughton
Jun 1, 1993·Behavioral Neuroscience·L M RomanskiJ E LeDoux
Feb 1, 1993·Neuroscience·K MuramotoM Fukuda
Dec 24, 1997·Nature·M G McKernan, P Shinnick-Gallagher
Jun 11, 1999·Neuroscience·D R CollinsD Paré
Jan 15, 2000·Science·J L McGaugh
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Feb 8, 2002·Neuron·György Buzsáki
May 13, 2003·Nature Neuroscience·Stephanie BissièreAndreas Lüthi
Aug 2, 2003·Nature·Kenneth D HarrisGyörgy Buzsáki
Aug 9, 2003·Science·Thomas SeidenbecherHans-Christian Pape
Jun 26, 2004·Annual Review of Neuroscience·James L McGaugh
Oct 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Valérie WespatatWolf Singer
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth P Bauer, Joseph E LeDoux
Apr 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hugh T BlairJason W Tarpley
Apr 18, 2006·Biological Psychiatry·Mark E BoutonStephen Maren
Aug 4, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter J UhlhaasEugenio Rodriguez
Aug 22, 2006·Neuropharmacology·Torfi SigurdssonJoseph E LeDoux
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ann E WilenskyJoseph E LeDoux
Dec 13, 2006·The European Journal of Neuroscience·James L Sinfield, Dawn R Collins
Dec 13, 2006·Molecular Psychiatry·K M Myers, M Davis
Apr 6, 2007·The European Journal of Neuroscience·Rajeevan T NarayananHans-Christian Pape
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kay M Tye, Patricia H Janak
Apr 21, 2007·Science·Jin-Hee HanSheena A Josselyn

❮ Previous
Next ❯

Citations

Mar 30, 2018·Nature Reviews. Neuroscience·Joseph LeDoux, Nathaniel D Daw
Apr 14, 2019·The Journal of Comparative Neurology·Alexander J McDonald, Franco Mascagni
Dec 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Elise Holter ThompsonMarianne Fyhn
Aug 7, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Aaron S Heller
Aug 2, 2019·The European Journal of Neuroscience·Lukasz BijochRafał Czajkowski
Aug 8, 2018·Science Advances·David TingleyDouglas Nitz
Feb 6, 2020·JAMA Psychiatry·Aaron S Heller, Rosemary C Bagot
Apr 14, 2020·Journal of Neuroscience Research·Matthew A GeramitaSusanne E Ahmari
Jul 15, 2020·The European Journal of Neuroscience·Marco CapognaArianna Maffei
Jun 1, 2018·Annals of Neurosciences·Anny Tzouma, Lazaros C Triarhou
Nov 13, 2018·Psychopharmacology·Gürsel Çalışkan, Oliver Stork
Mar 15, 2020·Nature Communications·Woong Bin Kim, Jun-Hyeong Cho
Jul 9, 2020·International Journal of Environmental Research and Public Health·Sagrario Pérez-de la Cruz
Jun 17, 2020·Network Neuroscience·Julien ModoloPascal Benquet
Aug 18, 2020·Translational Psychiatry·Josh M CislerClinton D Kilts
Aug 31, 2018·Scientific Reports·Sarit Soloduchin, Maoz Shamir
Mar 3, 2020·Frontiers in Neuroscience·Feng GaoXiang-Dong Sun
Jan 4, 2020·The Behavioral and Brain Sciences·Angelica Staniloiu, Hans J Markowitsch
Jul 1, 2020·PLoS Computational Biology·Nimrod Sherf, Maoz Shamir
Sep 13, 2018·Reviews in the Neurosciences·Catherine Pérez-ValenzuelaAlexies Dagnino-Subiabre
Aug 18, 2020·Molecular Brain·Jung-Pyo Oh, Jin-Hee Han
Jun 27, 2020·Frontiers in Neural Circuits·Cristian MoralesNoelia V Weisstaub
Mar 21, 2020·Frontiers in Computational Neuroscience·Samantha N SchummDavid F Meaney
Jul 28, 2020·Neuroscience and Biobehavioral Reviews·Matthew J Hartsock, Robert L Spencer
Jan 15, 2021·Brain Structure & Function·Zeinab KhastkhodaeiHeiko J Luhmann
Dec 20, 2020·Neurobiology of Learning and Memory·Sarah L FerriTed Abel
Jan 21, 2021·International Journal of Molecular Sciences·Daniela LaricchiutaLaura Petrosini
Jun 7, 2020·Behavioural Brain Research·Wendie N MarksJohn G Howland
Sep 25, 2020·Physiological Reviews·Mark E BoutonGavan P McNally
Mar 2, 2021·Neurobiology of Disease·Chiara FerrariSilvia Natoli
Mar 13, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Philipp BierwirthUrsula Stockhorst
Feb 25, 2018·Neurobiology of Learning and Memory·Gürsel Çalışkan, Oliver Stork
Apr 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Patrick SweeneyRoger D Cone

❮ Previous
Next ❯

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