Extra- and intracellular recordings in slices were used to examine what types of synaptic plasticity can be found in the core of the nucleus accumbens, and how these forms of plasticity may be modulated by dopamine. Stimulus electrodes were placed at the rostral border of the nucleus accumbens in order to excite primarily infralimbic and prelimbic afferents, as was confirmed by injections of the retrograde tracer fluoro-gold. In extracellular recordings, tetanization induced long-term potentiation (LTP) of the population spike in 20 out of 53 slices. The presynaptic compound action potential did not change following LTP induction. For the intracellularly recorded excitatory postsynaptic potentiation, three types of synaptic plasticity were noted: long-term potentiation (16 out of 54 cells), decremental potentiation (eight cells) and long-term depression (LTD; six cells). No correlation was found between the occurrence of potentiation or depression and various parameters of the tetanic depolarization (e.g. peak voltage, integral under the curve). The N-methyl-D-aspartate receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid (50 microM; D-AP5) reduced, but did not completely prevent, the induction of LTP. The incidence of LT...Continue Reading
Long-term potentiation and depression of synaptic responses in the rat hippocampus: localization and frequency dependency
Presynaptic dopamine D1 receptors attenuate excitatory and inhibitory limbic inputs to the shell region of the rat nucleus accumbens studied in vitro
Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat
Differential membrane properties and dopamine effects in the shell and core of the rat nucleus accumbens studied in vitro
Blockade of NMDA receptors unmasks a long-term depression in synaptic efficacy in rat prefrontal neurons in vitro
Contribution of NMDA receptors to postsynaptic potentials and paired-pulse facilitation in identified neurons of the rat nucleus accumbens in vitro
The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones
Light and electron microscopic analysis of projection neurons retrogradely labeled with Fluoro-Gold: notes on the application of antibodies to Fluoro-Gold
Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa
The basolateral amygdala-ventral striatal system and conditioned place preference: further evidence of limbic-striatal interactions underlying reward-related processes
The effect of dopaminergic D1 receptor blockade during tetanization on the expression of long-term potentiation in the rat CA1 region in vitro
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
Analysis of excitatory synaptic action in pyramidal cells using whole-cell recording from rat hippocampal slices
Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex.
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
Failure to reverse long-term potentiation by coupling sustained presynaptic activity and N-methyl-D-aspartate receptor blockade.
Dopaminergic antagonists prevent long-term maintenance of posttetanic LTP in the CA1 region of rat hippocampal slices.
Locally evoked potentials in slices of the rat nucleus accumbens: NMDA and non-NMDA receptor mediated components and modulation by GABA.
Role of prefrontal cortex and striatal output systems in short-term memory deficits associated with ageing, basal forebrain lesions, and cholinergic-rich grafts
The glutamate decarboxylase-, leucine enkephalin-, methionine enkephalin- and substance P-immunoreactive neurons in the neostriatum of the rat and cat: evidence for partial population overlap
Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study.
Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin
Excitatory amino acid projections to the nucleus accumbens septi in the rat: a retrograde transport study utilizing D[3H]aspartate and [3H]GABA
Postsynaptic control of the induction of long-term changes in efficacy of transmission at neocortical synapses in slices of rat brain
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
Cortical afferents of the nucleus accumbens in the cat, studied with anterograde and retrograde transport techniques
Nucleus accumbens to globus pallidus GABA projection: electrophysiological and iontophoretic investigations
Possible mechanisms for long-lasting potentiation of synaptic transmission in hippocampal slices from guinea-pigs
Responses of the nucleus accumbens following fornix/fimbria stimulation in the rat. Identification and long-term potentiation of mono- and polysynaptic pathways
Plasticity at hippocampal to prefrontal cortex synapses: dual roles in working memory and consolidation
Hippocampal and prefrontal cortical inputs monosynaptically converge with individual projection neurons of the nucleus accumbens
The ascending neuromodulatory systems in learning by reinforcement: comparing computational conjectures with experimental findings
Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation
The nucleus accumbens as a complex of functionally distinct neuronal ensembles: an integration of behavioural, electrophysiological and anatomical data
Synaptic activation of N-methyl-D-aspartate receptors induces short-term potentiation at excitatory synapses in the striatum of the rat
Dopamine reverses the depression of rat corticostriatal synapses which normally follows high-frequency stimulation of cortex in vitro
Muscimol-induced long-term depression in the hippocampus: lack of dependence on extracellular calcium
Inactivation of adenosine A2A receptor impairs long term potentiation in the accumbens nucleus without altering basal synaptic transmission
Effects of metabotropic glutamate receptor block on the synaptic transmission and plasticity in the rat medial vestibular nuclei
Possible pathways through which neurons of the shell of the nucleus accumbens influence the outflow of the core of the nucleus accumbens
Accumbal neurons that are activated during cocaine self-administration are spared from inhibitory effects of repeated cocaine self-administration
Withdrawal from repeated amphetamine administration reduces NMDAR1 expression in the rat substantia nigra, nucleus accumbens and medial prefrontal cortex
Cellular imaging with zif268 expression in the rat nucleus accumbens and frontal cortex further dissociates the neural pathways activated following the retrieval of contextual and cued fear memory
The NMDA receptor antagonist CPP suppresses long-term potentiation in the rat hippocampal-accumbens pathway in vivo
Developmental shift from long-term depression to long-term potentiation at the mossy fibre synapses in the rat hippocampus
Short- and long-term plasticity of the hippocampus to nucleus accumbens and prefrontal cortex pathways in the rat, in vivo
Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors
Temporal sequence learning, prediction, and control: a review of different models and their relation to biological mechanisms
Dopamine preferentially inhibits NMDA receptor-mediated EPSCs by acting on presynaptic D1 receptors in nucleus accumbens during postnatal development
Acute and chronic dopamine receptor stimulation modulates AMPA receptor trafficking in nucleus accumbens neurons cocultured with prefrontal cortex neurons.
Dopamine excites nucleus accumbens neurons through the differential modulation of glutamate and GABA release
Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core
Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens.
Electrical and pharmacological manipulations of the nucleus accumbens core impair synaptic plasticity in the dentate gyrus of the rat
Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.