Synaptic Plasticity in the Bed Nucleus of the Stria Terminalis: Underlying Mechanisms and Potential Ramifications for Reinstatement of Drug- and Alcohol-Seeking Behaviors

ACS Chemical Neuroscience
Nicholas A Harris, Danny G Winder

Abstract

The bed nucleus of the stria terminalis (BNST) is a component of the extended amygdala that shows significant changes in activity and plasticity through chronic exposure to drugs and stress. The region is critical for stress- and cue-induced reinstatement of drug-seeking behaviors and is thus a candidate region for the plastic changes that occur in abstinence that prime addicted patients for reinstatement behaviors. Here, we discuss the various forms of long-term potentiation (LTP) and long-term depression (LTD) in the rodent BNST and highlight the way that these changes in excitatory transmission interact with exposure to alcohol and other drugs of abuse, as well as other stressors. In addition, we highlight potential areas for future research in this area, including investigating input- and cell-specific bidirectional changes in activity. As we continue to accrue foundational knowledge in the mechanisms and effects of plasticity in the BNST, molecular targets and treatment strategies that are relevant to reinstatement behaviors will also begin to emerge. Here, we briefly discuss the effects of catecholamine receptor modulators on synaptic plasticity in the BNST due to the role of norepinephrine in LTD and dopamine on the shor...Continue Reading

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Citations

Feb 23, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dipanwita PatiThomas L Kash
Sep 27, 2018·Psychopharmacology·Travis D Goode, Stephen Maren
Nov 20, 2019·Neurobiology of Learning and Memory·Travis D GoodeStephen Maren
Feb 3, 2021·Social Neuroscience·Oscar E Prospero-GarciaMónica Mendez-Díaz
Nov 17, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonio FerragudPietro Cottone
Dec 15, 2020·Human Brain Mapping·Samuel C BerryThomas M Lancaster
Apr 13, 2021·Current Opinion in Pharmacology·Fabrizio Sanna, Maria Antonietta De Luca
May 15, 2021·Behavioural Brain Research·Mi-Seon Kong, Larry S Zweifel

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