Synaptic plasticity in the substantia gelatinosa in a model of chronic neuropathic pain

Neuroscience Letters
Robby J P JakenRonald Deumens

Abstract

Chronic neuropathic pain (CNP) is common after peripheral nerve injuries (PNI), but is rather refractory to available anti-pain medication. Advances in neuropathic pain research have identified cellular and molecular cues triggering the onset of neuropathic pain, but the mechanisms responsible for maintenance of chronic pain states are largely unknown. Structural changes such as sprouting of injured A-fibres into the substantia gelatinosa of the dorsal horn in the spinal cord have been proposed to relate to neuropathic pain in partial PNI models. Structural changes in central pain networks may also underlie the more persistent CNP following complete sectioning of a peripheral nerve, because this type of injury results in continuous and spontaneous afferent input to the spinal cord, which can trigger central sensitization. In the present study, the left sciatic nerve was completely sectioned and a 1-cm segment was removed to maintain a chronic pathology, whereas the right sciatic nerve was left intact. Mechanical allodynia was measured up to 84 days after injury, after which synaptic changes were studied in the lumbar substantia gelatinosa. The numbers of larger sized synaptophysin-immunoreactive presynaptic boutons were found t...Continue Reading

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Citations

Sep 24, 2011·Journal of Neurotrauma·Supinder S BediEdgar T Walters
Jul 12, 2012·Pain Practice : the Official Journal of World Institute of Pain·Helwin SmitsElbert A J Joosten
Apr 23, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Jeffrey E ArleJay L Shils
Nov 4, 2016·Annals of Biomedical Engineering·Nathan D Crosby, Beth A Winkelstein
Jan 27, 2021·International Journal of Pharmaceutics·Ricardo LorenzoniSilvia Stanisçuaski Guterres
Feb 16, 2011·Current Opinion in Supportive and Palliative Care

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