Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally

Brain Research
Richard J WurtmanGeorge Marzloff

Abstract

The synthesis of brain phosphatidylcholine may utilize three circulating precursors: choline; a pyrimidine (e.g., uridine, converted via UTP to brain CTP); and a PUFA (e.g., docosahexaenoic acid); phosphatidylethanolamine may utilize two of these, a pyrimidine and a PUFA. We observe that consuming these precursors can substantially increase membrane phosphatide and synaptic protein levels in gerbil brains. (Pyrimidine metabolism in gerbils, but not rats, resembles that in humans.) Animals received, daily for 4 weeks, a diet containing choline chloride and UMP (a uridine source) and/or DHA by gavage. Brain phosphatidylcholine rose by 13-22% with uridine and choline alone, or DHA alone, or by 45% with the combination, phosphatidylethanolamine and the other phosphatides increasing by 39-74%. Smaller elevations occurred after 1-3 weeks. The combination also increased the vesicular protein Synapsin-1 by 41%, the postsynaptic protein PSD-95 by 38% and the neurite neurofibrillar proteins NF-70 and NF-M by up to 102% and 48%, respectively. However, it had no effect on the cytoskeletal protein beta-tubulin. Hence, the quantity of synaptic membrane probably increased. The precursors act by enhancing the substrate saturation of enzymes th...Continue Reading

References

Feb 1, 1978·Journal of Neurochemistry·E M CornfordW H Oldendorf
Feb 13, 1976·Science·E L Cohen, R J Wurtman
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R M NitschR J Wurtman
Jun 1, 1974·Journal of Neurochemistry·D D Genchev, P Mandel
Mar 1, 1980·Analytical Biochemistry·C Labarca, K Paigen
Jun 1, 1982·Journal of Neurochemistry·W R Millington, R J Wurtman
Apr 1, 1997·Lipids·B M RossS J Kish
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·W Araki, R J Wurtman
Mar 1, 2000·Biochemical and Biophysical Research Communications·A Fujita, Y Kurachi
Sep 7, 2000·Biochemical Pharmacology·R J WurtmanL Yu
Aug 2, 2001·Journal of Molecular Neuroscience : MN·A A Spector
Aug 7, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Y LiW M Pardridge
May 23, 2002·Cellular and Molecular Life Sciences : CMLS·A Ferreira, M Rapoport
Oct 26, 2002·Science·Dennis J Selkoe
Nov 2, 2002·Journal of Paediatrics and Child Health·V Y H Yu
Apr 23, 2003·Brain Research·U Ingrid RichardsonRichard J Wurtman
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lisa A Teather, Richard J Wurtman
Apr 1, 1959·Journal of Neurochemistry·M LEESS CARR
Feb 20, 2004·Psychiatry Research·Suzann M BabbBruce M Cohen
Jan 19, 2005·The Journal of Biological Chemistry·Joseph R MarszalekHarvey F Lodish
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Carolina G GoncalvesMichael M Meguid
Aug 30, 2005·Brain Research·Mehmet CansevRichard J Wurtman
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Joseph R Marszalek, Harvey F Lodish

❮ Previous
Next ❯

Citations

Jul 9, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah HolguinRichard Wurtman
Aug 26, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P J Kamphuis, R J Wurtman
Apr 30, 2009·Annual Review of Nutrition·Richard J WurtmanIsmail H Ulus
Mar 15, 2014·The Journal of Nutrition, Health & Aging·C W RitchieP Passmore
Apr 26, 2014·Nutrients·Richard J Wurtman
Jan 1, 2014·High Altitude Medicine & Biology·Haydar Ali ErkenOsman Genç
Nov 21, 2008·Clinical and Experimental Hypertension : CHE·V BramantiR Avola
Mar 23, 2013·The Journal of Nutritional Biochemistry·Natalie ParlettaBarbara J Meyer
Aug 11, 2012·Pharmacology, Biochemistry, and Behavior·Berrak YetimlerEwa Jakubowska-Doğru
Aug 6, 2011·European Journal of Pharmacology·Martijn C de WildePhillip Scheltens
Aug 23, 2011·Journal of Structural Biology·Tarmo P RoosildGiuseppe Pizzorno
Aug 6, 2011·European Journal of Pharmacology·Richard J Wurtman
Mar 18, 2010·The Journal of Nutritional Biochemistry·Hui-Min Su
Feb 5, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Philip ScheltensAlexander Kurz
Sep 2, 2008·Neuroscience Research·Mehmet CansevRichard J Wurtman
Apr 22, 2008·Behavioural Brain Research·Sarah HolguinRichard Wurtman
Apr 2, 2008·European Journal of Pharmacology·Carlijn R Hooijmans, Amanda J Kiliaan
Apr 1, 2008·European Journal of Pharmacology·Eline M van der Beek, Patrick J G H Kamphuis
Jul 22, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mehmet CansevIsmail H Ulus
Apr 2, 2016·Neural Plasticity·Maximilian WiesmannAmanda J Kiliaan
Oct 30, 2016·Neuropharmacology·Lyl TomlinsonHolly Colognato
Mar 19, 2014·Acta Clinica Belgica·S EngelborghsM Vandewoude
Dec 8, 2011·Journal of Neurochemistry·Paul J M SavelkoulLaus M Broersen
Sep 28, 2015·Restorative Neurology and Neuroscience·Turkan KoyuncuogluTulin Alkan
Jun 14, 2006·Brain Research Reviews·Mehmet Cansev
Dec 30, 2014·Neuropharmacology·Mehmet CansevRichard J Wurtman
May 16, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Esra Orenlili YaylagulSerap Celikler Kasimogullari
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Deborah R GustafsonXiongwei Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.