PMID: 9427253Jan 14, 1998Paper

Synaptic refractory period provides a measure of probability of release in the hippocampus

Neuron
G O HjelmstadRobert C Malenka

Abstract

Despite extensive research, much controversy remains regarding the locus of expression of long-term potentiation (LTP) in area CA1 of the hippocampus, specifically, whether LTP is accompanied by an increase in the probability of release (p(r)) of synaptic vesicles. We have developed a novel method for assaying p(r), which utilizes the synaptic refractory period--a brief 5-6 ms period following release during which the synapse is incapable of transmission (Stevens and Wang, 1995). We show that this assay is sensitive to a battery of manipulations that affect p(r) but find no change following either NMDA receptor-dependent LTP or long-term depression (LTD).

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Citations

May 28, 2008·Journal of Computational Neuroscience·Dong SongTheodore W Berger
Aug 31, 2001·Progress in Neurobiology·N Kemp, Z I Bashir
Mar 11, 2000·The European Journal of Neuroscience·F AsztelyO Lindvall
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Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Adam J Granger, Roger A Nicoll
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