PMID: 8945764Nov 8, 1996Paper

Synaptic release rather than failure in the conditioning pulse results in paired-pulse facilitation during minimal synaptic stimulation in the rat hippocampal CA1 neurones

Neuroscience Letters
Y ChenH V Wheal

Abstract

In this paper we report our observations of the relationship of paired-pulse facilitation (PPF) with synaptic release or release failure at small numbers of synaptic sites. Minimal stimulation protocols were employed to enable the activation of only one or a few axons which synapse onto CA1 pyramidal cells in the hippocampus. Excitatory postsynaptic currents (EPSCs) in response to paired stimulation were measured. On the analysis of the data, we examined the effects of failure and synaptic release on PPF, and found that PPF was observed as a decrease in failures of synaptic release in response to test stimuli which were preceded by conditioning stimuli that evoked synaptic release. The test-pulse failure rate following conditioning pulse failures was indistinguishable from the overall conditioning pulse failure rate. It is postulated that the mechanism of paired-pulse facilitation is presynaptic and associated with successful synaptic release in response to the conditioning stimulus.

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Citations

May 4, 2013·Metabolic Brain Disease·Hamid Kalalian MoghaddamAbdolaziz Ronaghi
Jul 8, 1999·Current Opinion in Neurobiology·R S Zucker
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Suhita NadkarniHerbert Levine
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Apr 23, 2013·Alzheimer's Research & Therapy·Emilie Faivre, Christian Hölscher
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·P E Schulz
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·L E Dobrunz
Apr 3, 2010·Neurobiology of Aging·Simon GenglerChristian Hölscher
Apr 18, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Parham ReisiElaheh Soleimannejad
Feb 3, 2018·Neurochemical Research·Zhao-Hui YaoJi-Chang Hu
Mar 3, 2021·Acta Neuropathologica Communications·Selva BaltanBruce D Trapp

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