Synaptic remodeling and free radical formation after brain contusion injury in the rat

Experimental Neurology
O S JørgensenD G Stein

Abstract

The purpose of this study was to explore whether bilateral frontal cortex contusion in rats would demonstrate changes relevant for understanding the pathology of frontal lobe injury in humans. Rats were allowed to survive for 3, 7, or 18 days postinjury (dpi). In the contused rats, albumin was trapped in frontal cortices, as well as in other brain areas, showing that neurons were exposed to plasma components. In the sham-operated rats, which had only craniotomy but no penetration of dura, the level of trapped albumin was also increased compared to intact controls, suggesting a partial lesion-like condition. Choline acetyltransferase activity was severely decreased in the frontal cortices of contused rats, compared to the sham-operated controls. The decrease was most pronounced at 3 dpi and less pronounced 18 dpi, suggesting that after the initial damage, regeneration of the cholinergic terminals occurred. The concentration of the mature presynaptic membrane protein D3(SNAP-25) was also decreased in the frontal cortices of contused rats at 3 and 7 dpi, whereas it was normalized at 18 dpi. Previously, we have evaluated changes in the rate of synaptic remodeling in brain injury by calculating the ratio of the neural cell adhesion ...Continue Reading

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Citations

Aug 31, 2001·Journal of Neurotrauma·H A KasprzakB Woźniak
Dec 14, 2007·Annals of the New York Academy of Sciences·H NikizadV Jevtovic-Todorovic
Jan 20, 2010·Journal of Neuropathology and Experimental Neurology·Neil G HarrisRichard L Sutton
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Apr 23, 2003·The American Journal of Pathology·Bing ZhuMax S Cynader

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