Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge

Endocrinology
F NaftolinL M Garcia-Segura

Abstract

We have shown that the ovarian cycle is accompanied by a fall in the axosomatic synapses on randomly selected neurons of the arcuate nucleus by the morning of estrus, with a return to the preovulatory levels by the morning of metestrus, indicating a possible role in positive feedback. However, it remains to be proven that the circulating estradiol is the actual regulator of this physiological synaptic plasticity, or that estrogen-induced synaptic retraction precedes in the surge of gonadotropins at midcycle. To resolve these questions, we used an estradiol-immunoneutralization protocol and studied arcuate nucleus axosomatic synapses during the critical points of the estrous cycle. In addition to blocking positive feedback, estrogen immunoneutralization abolished synaptic retraction in the arcuate nucleus. As a positive control, the nonbinding estrogen diethylstilbestrol maintained the gonadotropin surge and synaptic retraction in the antiestradiol-treated animals. Furthermore, in the diluent-treated cycling control females, the synaptic retraction was found to precede the preovulatory LH surge. We demonstrated that the midcycle synaptic retraction of arcuate nucleus synapses is induced by the preovulatory estradiol surge, and t...Continue Reading

Citations

Aug 18, 2010·Reproductive Sciences·Peter SotonyiTamas L Horvath
Jul 8, 2017·The Journal of Comparative Neurology·Lisa M DiCarloRichard S Nowakowski
Nov 5, 1998·The Journal of Comparative Neurology·S LealM D Madeira
Aug 24, 1999·Journal of Neurobiology·G MorF Naftolin
Jun 19, 2004·Journal of Neurogenetics·Jean Marc Devaud, Alberto Ferrús
Mar 22, 2002·The European Journal of Neuroscience·Szatmár HorváthJózsef Toldi
Jul 21, 2004·Nature Reviews. Neuroscience·Tamas L Horvath, Sabrina Diano
Oct 7, 2004·Biopolymers·Roni KasherFortune Kohen
Jul 15, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura DazziGiovanni Biggio
Nov 3, 2009·The European Journal of Neuroscience·Marcelo O Dietrich, Tamas L Horvath
Mar 17, 2018·The Journal of Endocrinology·Luba SominskySarah J Spencer
Sep 1, 2006·Expert Review of Endocrinology & Metabolism·Miguel LópezCarlos Diéguez
Mar 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·Qian Gao, Tamas L Horvath
Apr 1, 1997·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·T L HorvathF Naftolin
Jan 13, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R AvolaB Marchetti
Jan 4, 2008·American Journal of Physiology. Endocrinology and Metabolism·Haifei ShiRandy J Seeley
Jan 1, 2016·Journal of Neuroendocrinology·J A LopezS M Hileman
Jul 29, 2003·Aging Cell·Iñigo AzcoitiaLuis M Garcia-Segura
Mar 11, 2003·Experimental Biology and Medicine·Krishnan M DhandapaniDarrell W Brann
Jul 17, 1998·Frontiers in Neuroendocrinology·N Chabbert BuffetP Bouchard
Nov 1, 2008·Brain Research·Paolo MiganiJennifer Rodger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.