Synaptic scaffolding molecule interacts with axin

Journal of Neurochemistry
Susumu HirabayashiYutaka Hata

Abstract

Synaptic scaffolding molecule (S-SCAM) is a synaptic protein that consists of PDZ domains, a guanylate kinase domain, and WW domains. It interacts with N-methyl-d-aspartate receptor subunits, neuroligin, and beta-catenin. Here, we identified Axin as a novel binding partner of S-SCAM. Axin was co-immunoprecipitated with S-SCAM from rat brain, detected in the post-synaptic density fraction in rat brain subcellular fractionation, and partially co-localized with S-SCAM in neurons. The guanylate kinase domain of S-SCAM directly bound to the GSK3beta-binding region of Axin. S-SCAM formed a complex with beta-catenin and Axin, but competed with GSK3beta for Axin-binding. Thereby, S-SCAM inhibited the Axin-mediated phosphorylation of beta-catenin by GSK3beta.

Citations

Mar 13, 2014·Human Molecular Genetics·Katharina BaußUwe Wolfrum
May 3, 2011·Journal of Neurodevelopmental Disorders·Nathan D Okerlund, Benjamin N R Cheyette
Jul 13, 2013·IUBMB Life·Yu ChenNancy Y Ip
Jun 26, 2007·Molecular and Cellular Neurosciences·Vahri BeaumontIgnacio Munoz-Sanjuan
Feb 1, 2015·Journal of Biochemistry·Shunta NagashimaYutaka Hata
Apr 4, 2006·Developmental Biology·Wataru NishimuraArun Sharma
Nov 24, 2004·Molecular and Cellular Neurosciences·Junko IidaYutaka Hata
Jul 12, 2007·Synapse·Shao-Jun Tang
Jun 6, 2006·Journal of Biochemistry·Akira KawataYutaka Hata
Jul 31, 2020·Journal of Cellular Physiology·Xiaolong XuJingwei Zhang

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