PMID: 2119486Jul 13, 1990Paper

Synaptic vesicle-bound phospholipase(s) acting on phosphatidylinositol exhibit(s) high susceptibility to brain ischemia

Neuroscience Letters
J StrosznajderA Gaiti

Abstract

The activity of phospholipase C acting against [3H]-inositol-phosphatidylinositol (PI) and the activity of arachidonic acid (AA) release from [1-14C]arachidonoyl-phosphatidylinositol by enzyme(s) located in synaptic vesicles (SV) isolated from normoxic and ischemic brains was investigated. Brain ischemia significantly activated phospholipase C (PhLC) by about 90% and AA release by about 50%. PhLC and AA release in SV isolated from brain submitted to ischemia were not further activated by 2 mM CaCl2 contrary to the enzymes from normoxic brain. The activation of PhLC and PhLA2 may produce conformational changes and rearrangement of the SV membranes leading to vesicle-membrane fusion and subsequently to massive neurotransmitter release known to occur during ischemia.

References

Jan 1, 1980·Annals of the New York Academy of Sciences·R J DeLorenzo
Mar 1, 1981·The Journal of Cell Biology·J E Heuser, T S Reese
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B E Burke, R J DeLorenzo
Jan 1, 1986·Neurochemistry International·J StrosznajderG Y Sun

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Citations

Oct 8, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J StrosznajderM Alberghina
Aug 4, 1999·Critical Reviews in Clinical Laboratory Sciences·E Kaiser

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