Synaptic vesicle cycle and amyloid β: Biting the hand that feeds

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Saak V OvsepianJ Oliver Dolly

Abstract

The synaptic vesicle cycle (SVC) holds center stage in the biology of presynaptic terminals. Through recurrent exocytosis and endocytosis, it facilitates a sequence of events enabling chemical neurotransmission between functionally related neurons. As a fundamental process that links the interior of nerve cells with their environment, the SVC is also critical for signaling and provides an entry route for a range of pathogens and toxins, enabling detrimental effects. In Alzheimer's disease, the SVC is both the prime site of amyloid β production and toxicity. In this study, we discuss the emerging evidence for physiological and pathological effects of Aβ on various stages of the SVC, from postfusion membrane recovery to trafficking, docking, and priming of vesicles for fusion and transmitter release. Understanding of the mechanisms of Aβ interaction with the SVC within the unifying calcium hypothesis of aging and Alzheimer's disease should further elucidate the fundamental biology of the presynaptic terminal and reveal novel therapeutic targets for Alzheimer's disease and other age-related dementias.

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Citations

Jul 28, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Saak V OvsepianJ Oliver Dolly
Mar 5, 2019·CNS Drugs·Brati Das, Riqiang Yan
May 8, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alexey M PetrovIrina A Pikuleva
Sep 29, 2019·Journal of Alzheimer's Disease : JAD·Francesca FagianiStefano Govoni
Dec 4, 2019·Frontiers in Neuroscience·Heinz Hillen
Jun 13, 2020·Frontiers in Endocrinology·Jennyfer MartínezCelia Quijano
Sep 23, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Saak Victor Ovsepian, Valerie Bríd O'Leary
Nov 9, 2018·Frontiers in Synaptic Neuroscience·Lennart Brodin, Oleg Shupliakov
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Saak V OvsepianCyril Hoschl
Oct 7, 2020·International Journal of Molecular Sciences·Tom L BroderickJeganathan Ramesh Babu
Dec 15, 2020·Neurobiology of Disease·Doris Lambracht-WashingtonRoger N Rosenberg
Jan 14, 2021·Cells·Dolores Siedlecki-WullichJosé Rodríguez-Álvarez
May 20, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Guzalia F ZakyrjanovaAlexey M Petrov

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