PMID: 8989397Oct 1, 1995Paper

Synaptically evoked prolonged depolarizations in the developing auditory system

Journal of Neurophysiology
V C Kotak, D H Sanes

Abstract

1. Although synaptic transmission is known to influence many aspects of neuronal development, activity rates are quite low at early ages. The present study describes a long-lasting postsynaptic response to brief periods of synaptic stimulation that may underlie such an influence. Whole-cell patch clamp recordings were made from the lateral superior olive (LSO) in a brain slice preparation from early postnatal gerbils. 2. Stimulation of the excitatory afferent pathway from the cochlear nucleus elicited a prolonged depolarization (PD) in approximately 60% of the LSO neurons tested. Low frequency stimulation (1 Hz) was as effective as tetanic stimulation in producing PDs. These synaptically evoked depolarizations ranged in amplitude from 3 to 32 mV and recovered spontaneously after 0.5-35 min. 3. The LSO neuron input resistance declined during every PD episode and remained significantly lower even after the membrane potential had recovered. These PDs were partially reversed by 2 mM Ni(+2), but 1 microM tetrodotoxin and 10 microM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) were ineffective. The metabotropic glutamate receptor agonist, trans-1-aminocyclopentane-1,3-dicarboxylic acid (40 microM), produced depolarizations that outlast...Continue Reading

Citations

Feb 13, 1999·The European Journal of Neuroscience·A Caicedo, M Eybalin
May 2, 2002·The European Journal of Neuroscience·Paul H M KullmannKarl Kandler
Oct 3, 2002·Journal of Neurobiology·Vibhakar C Kotak, Dan H Sanes
Aug 26, 2003·The Journal of Physiology·Walter MarcottiCorne J Kros
Jun 15, 2006·The Journal of Membrane Biology·D DulonR L Davis
Nov 2, 2007·Nature·Nicolas X TritschDwight E Bergles
Mar 3, 2009·Journal of the Association for Research in Otolaryngology : JARO·María Eugenia Gómez-CasatiEleonora Katz
Apr 22, 2015·Cell and Tissue Research·Eckhard FriaufMartin F Fuhr
Jun 16, 1999·Journal of Neurophysiology·K K Fitzgerald, D H Sanes
Dec 21, 2002·The European Journal of Neuroscience·Carmen Vale, Dan H Sanes
Aug 10, 2007·Journal of Neurophysiology·Timothy A JonesBen Bonham
Oct 10, 2014·Cell and Tissue Research·Han Chin Wang, Dwight E Bergles
Aug 10, 2001·Journal of Neurophysiology·T J AdamD W Schwarz
Jun 15, 2006·The Journal of Membrane Biology·G D HousleyE N Yamoah
Feb 17, 1998·The European Journal of Neuroscience·V C Kotak, D H Sanes
May 28, 2009·Nature Neuroscience·Karl KandlerJihyun Noh
Jan 29, 2008·Cerebral Cortex·Vibhakar C KotakDan H Sanes
Oct 1, 2009·The European Journal of Neuroscience·Benjamin HassfurthUrsula Koch
Jul 6, 2014·Frontiers in Neural Circuits·Vibhakar C Kotak, Dan H Sanes
Nov 12, 2014·Frontiers in Neurology·Benjamin D AuerbachRichard J Salvi
Feb 2, 2019·The European Journal of Neuroscience·Victor S C WongDianna E Willis
May 28, 2019·Frontiers in Cellular Neuroscience·Holly A HolmanRichard D Rabbitt
Sep 29, 2004·The European Journal of Neuroscience·Carmen ValeDan H Sanes
Dec 1, 1996·Journal of Neurobiology·D H Sanes, A Hafidi

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