PMID: 8960293Jan 1, 1996Paper

Synaptogenesis in the neocortical anlage and early developing neocortex of rat embryos

Acta Anatomica
Y BalslevK Møllgård

Abstract

The recent finding of synapses in Monodelphis domestica (South American grey short-tailed opossum) before the establishment of the cortical plate raises the question of whether this finding is species-specific. Therefore, the establishment of the first synapses in the developing neocortex has been studied in the sensorimotor cortex of rat fetuses with a gestational age ranging from embryonic day 12 (E12) to birth. At E14, we found well-defined synapses with postsynaptic thickening and containing several vesicles in the presynaptic element in the primordial plexiform layer, before the appearance of the cortical plate. The postsynaptic elements were probably dendrites of Cajal-Retzius cells in the primordial plexiform layer and/or differentiating dendrites of presumptive cortical plate neurons. At E16, in addition to the presence of axodendritic and very few axosomatic synapses in the marginal and the subplate zones, synapses of both types were present within the cortical plate. Thus, this paper provides evidence for the presence of synapses in the developing rat brain both at an earlier stage and with a wider distribution than previously reported.

Citations

Jun 6, 2012·Pflügers Archiv : European journal of physiology·Anton DvorzhakSergei Kirischuk
Jan 23, 2013·International Journal of Molecular Medicine·Nada SamariMohammed Abderrafi Benotmane
Sep 5, 2002·Nature Reviews. Neuroscience·David F Owens, Arnold R Kriegstein
Oct 12, 2007·Physiological Reviews·Yehezkel Ben-AriRustem Khazipov
Aug 13, 1999·Journal of Neurophysiology·D F OwensA R Kriegstein
Jun 6, 2018·Frontiers in Molecular Neuroscience·Anna GorelikOrly Reiner
Aug 24, 2017·Developmental Medicine and Child Neurology·Mijna Hadders-Algra
Jan 1, 2021·Developmental Neurobiology·Martyna PekalaKatarzyna Kalita

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