PMID: 2104823Jan 1, 1990Paper

Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms

Human Pathology
D C MillerD E Burstein

Abstract

Synaptophysin, a 38-kilodalton glycoprotein found in synaptic vesicle membranes, has been shown to be a sensitive marker of neuroendocrine differentiation in non-central nervous system (CNS) tumors. We analyzed the patterns of synaptophysin immunoreactivity in CNS neoplasms in comparison with various normal CNS sites in biopsies. Normal gray matter structures all showed a diffuse punctate granular pattern of neuropil staining without staining of neuronal cell bodies. In contrast, neoplastic ganglion cells in 18 of 18 gangliogliomas/gangliocytomas showed intense immunoreactivity outlinging the borders of the cell bodies. Focal staining was also seen in five of 16 primitive neuroectodermal tumors and in one of three central neurocytomas, but these tumors had a finely granular neuropil pattern of immunoreactivity more like that of normal gray matter than like that of the gangliogliomas. All 35 examples of pure gliomas of various types showed no immunoreactivity. Our data highlight synaptophysin as a sensitive and specific marker of both neuronal lineage and neoplastic character in gangliogliomas.

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Citations

Sep 1, 1996·Journal of Clinical Pathology·V Soontornniyomkij, R I Schelper
May 12, 1998·Journal of Neurosurgery·B Quinn
May 1, 1995·Journal of Child Neurology·K W MinR A Brumback
Apr 27, 2007·Neurosurgery·Ricardo J KomotarPaul C McCormick
Jan 1, 1996·Acta Neuropathologica·S PattH Kettenmann
Aug 15, 1994·Journal of Neuroscience Research·M WestphalH D Herrmann
May 20, 1998·The American Journal of Surgical Pathology·B Quinn
Oct 20, 1998·The American Journal of Surgical Pathology·T KomoriM Kobayashi
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ellen GelpiHerbert Budka
Nov 25, 2020·Neurosurgery·Diana L Thomas, Christopher R Pierson

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