PMID: 2107138Mar 1, 1990Paper

Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms

Human Pathology
D C MillerD E Burstein

Abstract

Synaptophysin, a 38-kilodalton glycoprotein found in synaptic vesicle membranes, has been shown to be a sensitive marker of neuroendocrine differentiation in non-central nervous system (CNS) tumors. We analyzed the patterns of synaptophysin immunoreactivity in CNS neoplasms in comparison with various normal CNS sites in biopsies. Normal gray matter structures all showed a diffuse punctate granular pattern of neuropil staining without staining of neuronal cell bodies. In contrast, neoplastic ganglion cells in 18 of 18 gangliogliomas/gangliocytomas showed intense immunoreactivity outlining the borders of the cell bodies. Focal staining was also seen in five of 16 primitive neuroectodermal tumors and in one of three central neurocytomas, but these tumors had a finely granular neuropil pattern of immunoreactivity more like that of normal gray matter than like that of the gangliogliomas. All 35 examples of pure gliomas of various types showed no immunoreactivity. Our data highlight synaptophysin as a sensitive and specific marker of both neuronal lineage and neoplastic character in gangliogliomas.

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Citations

Dec 1, 1993·Journal of Neurosurgery·D C MillerF J Epstein
Dec 1, 1993·Journal of Neurosurgery·F F LangD C Miller
Dec 1, 1996·Journal of Neurosurgery·S ConstantiniF J Epstein
Oct 19, 2007·Journal of Neurosurgery·Brian D MilliganMichael J Link
Nov 21, 2002·Pathology, Research and Practice·Anna Maria BuccolieroGian Luigi Taddei
Apr 27, 2007·Neurosurgery·Ricardo J KomotarPaul C McCormick
Oct 12, 2004·Arquivos de neuro-psiquiatria·Guilherme BorgesJose Ribeiro Menezes
Aug 31, 2006·Neurosurgical Review·Mehar Chand SharmaChitra Sarkar
Dec 14, 2006·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jean-Pierre de ChadarévianChristos D Katsetos
Mar 5, 2009·Journal of Child Neurology·Luca MassimiConcezio Di Rocco
Jul 13, 2014·American Journal of Clinical Pathology·Seth C LummusB K Kleinschmidt-DeMasters
Feb 1, 1997·The American Journal of Surgical Pathology·F GiangasperoP C Burger
Mar 1, 1996·The American Journal of Surgical Pathology·P J Zhang, M K Rosenblum
Sep 25, 2020·British Journal of Neurosurgery·Amad KhanAli Nader-Sepahi
Aug 1, 1993·Journal of Neuro-oncology·H G KrouwerM D Prados
Dec 25, 1995·The Journal of Comparative Neurology·T H SwansonS A Rivkees
Jan 26, 2021·The Journal of Biological Chemistry·Junjie YueZhuojuan Luo
Apr 13, 2001·Archives of Pathology & Laboratory Medicine·C D KatsetosK Khalili
Aug 1, 1994·Critical Reviews in Oncology/hematology·W M Molenaar, J Q Trojanowski
Oct 3, 2003·Pathology, Research and Practice·Figen SoylemezogluMustafa Berker

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