PMID: 7086430Aug 1, 1982Paper

Synaptosomal calcium uptake systems: prostaglandins are probably not involved in the regulation of calcium fluxes into and within the nerve endings

Journal of Neurochemistry
C DenzlingerR Jackisch


45Ca2+ uptake measurements were performed on intact and osmotically lysed synaptosomes from rat brain to study the possible influence of prostaglandins (PGs) on Ca2+ movements into and within the nerve endings. The K+-induced 45Ca2+ uptake of intact synaptosomes was not influenced by several inhibitors of PG synthesis. 45Ca2+ uptake in lysed synaptosomal preparations was promoted by ATP and seemed to be largely attributable to mitochondria, as it was inhibited by mitochondrial poisons. This Ca2+ uptake was strongly reduced by PG synthesis inhibitors but also by PG precursor fatty acids. Both PG synthesis inhibitors and precursors, according to their relative efficacy in blocking Ca2+ uptake, were able to induce Ca2+ efflux from preloaded intrasynaptosomal organelles. The PGs E2, F2 alpha, D2, and thromboxane B2 were without effect on 45Ca2+ uptake in lysed synaptosomal preparations. On the basis of our results it does not seem likely that PGs influence Ca2+ availability by modulating Ca2+ fluxes into or within the nerve endings. The observed inhibitory effects of PG synthesis inhibitors and precursors on the intrasynaptosomal Ca2+ uptake might be due to unspecific impairment of mitochondrial functions.


Mar 1, 1976·Journal of Neurochemistry·G RaffelG Hertting
May 1, 1979·Biophysical Journal·D A Nachshen, M P Blaustein
Jul 12, 1979·Biochemical and Biophysical Research Communications·S T Ohnishi, T M Devlin
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·P Hedqvist
Oct 1, 1977·Physiological Reviews·T C Westfall
Jun 1, 1975·The Journal of Physiology·M P Blaustein, C J Oborn
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Jun 30, 1976·Experimental Brain Research·G R Vickers, M J Dowdall
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Jan 1, 1980·British Journal of Pharmacology·J GripenbergS E Jansson
Jan 1, 1981·Reviews of Physiology, Biochemistry and Pharmacology·A B Borle

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