PMID: 3746299Oct 1, 1986Paper

Synaptosomal sialyltransferase glycosylates surface proteins that are inaccessible to the action of membrane-bound sialidase

Journal of Neurochemistry
K C Breen, C M Regan

Abstract

Sialyltransferase has been characterized in P2 pellets derived from animals of increasing age. The enzyme was found to be associated with the plasma membrane and to be developmentally regulated at times coincident with cell migration and fibre outgrowth. This regulation appeared to be due, in part, to an endogenous competitive inhibitor in the P2 pellet but not in the synaptosome. Optimal transfer of [14C]N-acetylneuraminic acid to endogenous synaptosomal acceptors was achieved only in the absence of detergent. Furthermore, the transferred sialic acid was found to be inaccessible to the action of membrane-bound sialidase. The significance of these findings is discussed.

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D D Pless, W J Lennarz
Aug 21, 1975·Nature·C W Porter, R J Bernacki
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·K ArtztF Jacob
Sep 1, 1983·The Biochemical Journal·C O'FagainT J Mantle
Feb 4, 1983·Science·G M Edelman
Feb 1, 1982·Computers and Biomedical Research, an International Journal·W R GrecoW Korytnyk
Jan 1, 1980·The Journal of Cell Biology·R BretzG E Palade

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Citations

May 1, 1995·Neurochemical Research·C M Regan, G B Fox
Dec 24, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C L BaconC M Regan
May 20, 1998·Molecular Neurobiology·K C BreenF D Hayes
Jan 10, 2002·Biochimica Et Biophysica Acta·Elena V GrachevaNina V Prokazova
Aug 1, 1989·Pharmacology, Biochemistry, and Behavior·J Mathew, W R Klemm
Jan 1, 1991·The International Journal of Biochemistry·P BroquetP Louisot
Jan 1, 1991·The International Journal of Biochemistry·C M Regan
May 1, 1988·Alcohol·W R KlemmR G Maring
Jan 1, 1994·Neurobiology of Aging·T M MaguireK C Breen
Jul 21, 2000·Annals of Clinical Biochemistry·P MoutsatsouH Cuckle

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