Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity

Genes & Development
Masafumi ShimojoAnton Maximov

Abstract

Synaptotagmin-11 (Syt11) is a Synaptotagmin isoform that lacks an apparent ability to bind calcium, phospholipids, or SNARE proteins. While human genetic studies have linked mutations in the Syt11 gene to schizophrenia and Parkinson's disease, the localization or physiological role of Syt11 remain unclear. We found that in neurons, Syt11 resides on abundant vesicles that differ from synaptic vesicles and resemble trafficking endosomes. These vesicles recycle via the plasma membrane in an activity-dependent manner, but their exocytosis is slow and desynchronized. Constitutive knockout mice lacking Syt11 died shortly after birth, suggesting Syt11-mediated membrane transport is required for survival. In contrast, selective ablation of Syt11 in excitatory forebrain neurons using a conditional knockout did not affect life span but impaired synaptic plasticity and memory. Syt11-deficient neurons displayed normal secretion of fast neurotransmitters and peptides but exhibited a reduction of long-term synaptic potentiation. Hence, Syt11 is an essential component of a neuronal vesicular trafficking pathway that differs from the well-characterized synaptic vesicle trafficking pathway but is also essential for life.

References

Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·L VicianH R Herschman
Mar 10, 2001·Nature·R Fernández-ChacónT C Südhof
Dec 12, 2001·The Journal of Biological Chemistry·Thomas C Südhof
Feb 26, 2003·Cell·Reinhard JahnThomas C Südhof
Aug 18, 2004·Nature Structural & Molecular Biology·Han DaiJosep Rizo
Dec 6, 2006·Genesis : the Journal of Genetics and Development·Sandra GoebbelsKlaus-Armin Nave
Dec 28, 2006·The Journal of Cell Biology·Anton MaximovThomas C Südhof
Dec 29, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhiping P PangThomas C Südhof
Dec 29, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Shinichi InoueMichio Oishi
Nov 30, 2007·Nature·Jianyuan SunThomas C Südhof
Jan 28, 2009·The Journal of Physiology·Natalia GustavssonWeiping Han
Oct 27, 2009·FEBS Letters·Alfonso Gonzalez, Enrique Rodriguez-Boulan
Nov 26, 2009·Nature Reviews. Molecular Cell Biology·Nobutaka HirokawaYasushi Okada
Jan 27, 2012·Journal of Neurophysiology·Xiaoyu PengRita J Balice-Gordon
Apr 20, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Camin DeanEdwin R Chapman
Jun 25, 2013·Neuropharmacology·Elke EdelmannTanja Brigadski
Sep 23, 2014·The Journal of Clinical Investigation·Qiuyu ZhuCharles J Lowenstein
May 12, 2015·Cell Reports·Masafumi ShimojoAnton Maximov
Nov 22, 2015·EMBO Reports·Changhe WangZhuan Zhou
Mar 6, 2016·Journal of the Neurological Sciences·Angel SesarMaría-Jesús Sobrido

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Citations

Nov 9, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Anne GieselerKarl-Heinz Zacher
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuxin YanClaire Xi Zhang
Aug 14, 2020·International Journal of Molecular Sciences·C Alejandra Morato TorresBirgitt Schüle
Jan 30, 2021·ACS Chemical Neuroscience·Subathra RadhakrishnanShanmugaapriya Sellathamby
Feb 14, 2021·Molecular and Cellular Neurosciences·Hiroshi Kawabe, Judith Stegmüller
Feb 24, 2021·Cellular and Molecular Life Sciences : CMLS·Mónica C Quiñones-Frías, J Troy Littleton
Mar 4, 2021·Alzheimer's Research & Therapy·Julia RemnestålAnna Månberg
Jul 15, 2020·Current Opinion in Neurobiology·Anne C Wolfes, Camin Dean
Sep 26, 2020·Neuroscience Letters·Yalong WangClaire Xi Zhang
Jul 24, 2021·Cerebral Cortex Communications·Odile BartholomeBernard Rogister
Jul 10, 2021·Ageing Research Reviews·Adiv A JohnsonBenoit Lehallier
Oct 13, 2021·Neurochemical Research·Abhishek Kumar Mishra, Anubhuti Dixit
Oct 3, 2021·Journal of Neurochemistry·Wan-Ru LiClaire Xi Zhang

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