Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes

Cell and Tissue Research
P Redecker

Abstract

Recent studies have shown that mammalian pinealocytes contain a compartment of synaptic-like microvesicles that may serve secretory functions; however, knowledge of the molecular composition of these microvesicles is still incomplete. Therefore, we have analyzed rat and gerbil pineal glands for the presence of synaptotagmin I, synaptobrevin I and II, syntaxin I, and synaptoporin (synaptophysin II) by immunoblot analyses and immunostaining of serial semithin sections. These proteins, which are components of the synaptic vesicle membrane or presynaptic plasmalemma, are thought to be essential for synaptic vesicle trafficking and exocytosis. Antibodies against synaptotagmin I, synaptobrevin II, and syntaxin I label pinealocytes (identified with an antiserum directed against synaptophysin I) in pineal glands of both species, the coexpression of the latter proteins being demonstrable at the single cell level. In contrast, pinealocytes are not or only weakly stained by the synaptoporin antibody. Immunoreactivity for synaptobrevin I is restricted to intrapineal nerve terminals, thus indicating a differential expression of synaptic vesicle protein isoforms within endocrine tissues. Immunogold staining has been performed in the gerbil p...Continue Reading

Citations

Mar 1, 1997·Journal of Neuroscience Research·P RedeckerS Steinlechner
May 6, 2005·Histochemistry and Cell Biology·Peter Redecker
Mar 3, 2009·Molecular Neurobiology·George Zanazzi, Gary Matthews
Dec 31, 1997·Neurochemistry International·K Langley, N J Grant
Aug 1, 1996·Journal of Pineal Research·P RedeckerD Grube
Jan 29, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jeffrey B BiceAnthony Montanaro
May 20, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Peter RedeckerTobias M Boeckers
Apr 17, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P RedeckerT M Boeckers
Jan 14, 1999·Journal of Neurochemistry·N J GrantK Langley

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