Synaptotagmins bind calcium to release insulin

American Journal of Physiology. Endocrinology and Metabolism
Benoit R Gauthier, Claes B Wollheim

Abstract

Plasma insulin levels are determined mainly by the rate of exocytosis of the insulin-containing large dense core vesicles (LDCVs) of pancreatic islet beta-cells. This process involves the recruitment of LDCVs to the plasma membrane, where they are docked by the assembly of multiprotein SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes. However, fusion of the two membranes will proceed only in the presence of Ca(2+) ions, implicating a Ca(2+) sensor protein. The synaptotagmin gene family, comprising 15 members, was proposed to act as such Ca(2+) sensor in regulated exocytosis in neurons and neuroendocrine and endocrine cells. Herein, we review the physiological function of the various synaptotagmins with reference to their impact on insulin exocytosis. Cumulating evidence emphasizes the crucial role of synaptotagmin VII and IX as mediators of glucose-induced insulin secretion.

References

Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·A W Hudson, M J Birnbaum
Mar 20, 1995·FEBS Letters·M Craxton, M Goedert
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·G JacobssonB Meister
Jan 1, 1994·Journal of Cellular Biochemistry·F M AshcroftP Rorsman
Jan 1, 1995·Journal of Physiology, Paris·M LinialD Parnas
Apr 9, 1999·Nature Neuroscience·J M IlardiZ H Sheng
Nov 1, 2000·Nature Cell Biology·N OzakiS Seino
Apr 21, 2001·Cellular and Molecular Life Sciences : CMLS·B Adolfsen, J T Littleton
Jul 5, 2001·The Journal of Biological Chemistry·T CoppolaR Regazzi
Dec 12, 2001·The Journal of Biological Chemistry·Thomas C Südhof
May 15, 2002·The Journal of Biological Chemistry·Chika SaegusaKatsuhiko Mikoshiba
Jun 20, 2002·The Biochemical Journal·Mitsunori FukudaKatsuhiko Mikoshiba
Jul 25, 2003·Diabetologia·P Rorsman, E Renström
Aug 20, 2003·The Journal of Cell Biology·Sabyasachi ChakrabartiNorma W Andrews
Oct 1, 2003·Molecular Biology of the Cell·Laurent WaselleRomano Regazzi
May 6, 2004·Journal of Cell Science·Amar AbderrahmaniGérard Waeber
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Masanari MatsumotoSusumu Seino
Jun 11, 2004·Journal of Cell Science·Mariella IezziClaes B Wollheim
Jun 26, 2004·Annual Review of Neuroscience·Thomas C Sudhof
Oct 1, 2004·The Journal of Biological Chemistry·Mitsunori FukudaAkitsugu Yamamoto
Nov 25, 2004·The Journal of Biological Chemistry·Weiping HanThomas C Südhof
Nov 25, 2004·Diabetes·Gordon C Weir, Susan Bonner-Weir
Mar 25, 2005·Molecular Biology of the Cell·Aniko VaradiGuy A Rutter
Sep 20, 2005·Trends in Cell Biology·Norma W Andrews, Sabyasachi Chakrabarti
Sep 27, 2005·Physiological Reviews·Susumu Seino, Tadao Shibasaki

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Citations

May 15, 2012·Journal of Proteome Research·Alexandra C Schrimpe-RutledgeThomas O Metz
Feb 22, 2011·Nature Structural & Molecular Biology·Zhixiong XuGary Felsenfeld
Apr 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Morten Gram Pedersen, Arthur Sherman
Mar 20, 2012·Molecular & Cellular Proteomics : MCP·Domitille SchvartzJean-Charles Sanchez
Apr 12, 2012·American Journal of Physiology. Cell Physiology·Susanne G Straub, Geoffrey W G Sharp
Jul 9, 2009·American Journal of Physiology. Endocrinology and Metabolism·Seung-Ryoung JungIan R Sweet
Jan 21, 2011·Physiological Reviews·James A McCormick, David H Ellison
Nov 6, 2013·Diabetologia·Ruth Gutierrez-AguilarRandy J Seeley
Nov 11, 2014·Genes·Jonathan L S EsguerraLena Eliasson
Jul 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Bingbing WuWeiping Han
Sep 17, 2011·Progress in Biophysics and Molecular Biology·Leonid E Fridlyand, Louis H Philipson
Sep 24, 2015·Differentiation; Research in Biological Diversity·So-Yeon KimJoo-Won Park
Sep 6, 2011·Redox Report : Communications in Free Radical Research·Letícia P RomaKleber L A Souza
Mar 2, 2011·Cell Metabolism·Woo-Jin SongMehboob A Hussain
Jul 26, 2011·Molecular and Cellular Endocrinology·Andreas Wiederkehr, Claes B Wollheim
Nov 4, 2016·Epigenomics·Trine B RoungeElisabete Weiderpass
Oct 13, 2016·Journal of Neurochemistry·Paulo S PinheiroJakob B Sørensen
Jan 1, 2012·Biomolecules·Elisa VergariPatrick E MacDonald
Nov 11, 2017·Physiological Reports·Vishal A SalunkheLena Eliasson
Mar 31, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Arianne Aslamy, Debbie C Thurmond
Aug 21, 2008·American Journal of Physiology. Endocrinology and Metabolism·Philippe A Halban
Sep 22, 2011·American Journal of Physiology. Endocrinology and Metabolism·Patrick E MacDonald
Jun 22, 2011·The Journal of Biological Chemistry·Slavena A MandicChristina Bark
May 11, 2019·Genes·Esther Fuente-MartínBenoit R Gauthier

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