Synaptotagmins: That's Why So Many

Neuron
Chong Chen, Peter Jonas

Abstract

Synaptotagmin 7 (Syt7) was originally identified as a slow Ca(2+) sensor for lysosome fusion, but its function at fast synapses is controversial. The paper by Luo and Südhof (2017) in this issue of Neuron shows that at the calyx of Held in the auditory brainstem Syt7 triggers asynchronous release during stimulus trains, resulting in reliable and temporally precise high-frequency transmission. Thus, a slow Ca(2+) sensor contributes to the fast signaling properties of the calyx synapse.

References

Dec 12, 2001·The Journal of Biological Chemistry·Thomas C Südhof
Mar 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Enfu HuiEdwin R Chapman
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Angharad M KerrPeter Jonas
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hua WenPaul Brehm
Jan 8, 2016·Nature·Skyler L JackmanWade G Regehr

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Citations

Jan 31, 2019·Frontiers in Molecular Neuroscience·Grit Bornschein, Hartmut Schmidt
Jun 7, 2018·Frontiers in Computational Neuroscience·Elham Bayat MokhtariEmily F Stone
May 1, 2018·Trends in Cell Biology·Axel T BrungerYing Lai
Jul 24, 2021·Cerebral Cortex Communications·Odile BartholomeBernard Rogister
Sep 2, 2021·The Journal of Comparative Neurology·Diane HenryLonnie P Wollmuth

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