Synbiotic effect of Lactobacillus helveticus M92 and prebiotics on the intestinal microflora and immune system of mice

The Journal of Dairy Research
J FreceJ Susković

Abstract

The synbiotic effect of the oral treatment of Swiss albino mice with milk-based diets supplemented with Lactobacillus helveticus M92 and various kinds of prebiotics was investigated. Survival, competition, adhesion and colonization, as well as, immunomodulating capability of Lb. helveticus M92, in synbiotic combination, in the gastrointestinal tract (GIT) of mice, were monitored. After the mice were fed with synbiotics, the lactic acid bacteria (LAB) counts in faeces were increased and reduction of enterobacteria and sulphite-reducing clostridia was observed. Similar results were obtained in homogenates of small and large intestine of mice on the 1st and 14th day, after feeding with synbiotics. After the mice were orally given viable Lb. helveticus M92 cells, alone or in combination with prebiotic, the concentration of faecal SIgA and total serum IgA antibodies from all immunized mice were higher compared with the control. The specific humoral immune response was not evoked after oral administration, therefore their synbiotic application is suitable. Among inulin, lactulose and raffinose, Lb. helveticus M92 in combination with inulin, has shown the best synbiotic effect on intestinal and faecal microflora and immune system of m...Continue Reading

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Citations

Feb 18, 2011·Antonie van Leeuwenhoek·Jasna BeganovićJagoda Sušković
Feb 9, 2012·Bioscience, Biotechnology, and Biochemistry·Takashi NakamuraHisashi Aso
Mar 5, 2013·Anaerobe·Jasna BeganovićJagoda Šušković
Aug 4, 2011·European Journal of Pharmacology·Caroline G M de TheijeAletta D Kraneveld
Sep 24, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D P SinghM Bishnoi
Jan 27, 2015·Applied and Environmental Microbiology·Janina A KrumbeckJens Walter
Jan 1, 2012·Bioscience of Microbiota, Food and Health·Keisuke OzawaKei Sonoyama
Jul 12, 2019·Frontiers in Microbiology·Alessandra FontanaLorenzo Morelli

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