Synchronicity of nociceptive and non-nociceptive adjacent neurons in the spinal dorsal horn of the rat: stimulus-induced plasticity

Neuroscience
A Eblen-Zajjur, J Sandkühler

Abstract

Current knowledge of spinal processing of sensory information is largely based on single-cell recordings; however, temporal correlation of multiple cell discharges may play an important role in sensory encoding, and single electrode recordings of several neurons may provide insights into the functions of a neuronal network. The technique was applied to the lumbar spinal dorsal horn of pentobarbital-anaesthetized rats during background activity, steady-state noxious heat stimulation (48 degrees C, 100 s), cold block spinalization or radiant heat-induced inflammation of the skin, and the recordings were evaluated by means of auto-correlation, autospectral and cross-correlation analysis. Background patterns obtained by these three methods were extremely stable in time. Autocorrelation with short lag peaks was observed in 72.2% of neurons (n = 223). Background correlated discharges were found in 83.6% of the neuron pairs (n = 134). Cross-correlation with a central peak, suggestive of common input to the recorded cells, was the most common pattern observed in almost all laminae and was associated with high incidence (91.8%) of overlapping receptive fields and with neurons with initial peak autocorrelation pattern. Cross-correlations...Continue Reading

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Citations

Feb 13, 2001·Brain Research·H D Schwark, O B Ilyinsky
Feb 13, 1999·Progress in Neurobiology·M J Millan
Sep 5, 2008·Neural Plasticity·Douglas A Caruana, C Andrew Chapman
Aug 8, 2013·Somatosensory & Motor Research·Verónika Storaci, Antonio Eblen-Zajjur
Aug 19, 2009·The European Journal of Neuroscience·Eduardo MalmiercaAngel Nuñez
May 22, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·J Meléndez-Gallardo, A Eblen-Zajjur

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