Synchronization of oxytocin neurons in suckled rats: possible role of bilateral innervation of hypothalamic supraoptic nuclei by single medullary neurons

The European Journal of Neuroscience
F MoosGérard Alonso

Abstract

We have previously shown that oxytocin neurons located in the four hypothalamic magnocellular nuclei display synchronous bursts of action potentials before each milk ejection. The mechanisms involved in such a synchronization have, however, not yet been elucidated. In this study, we test the hypothesis of an extranuclear synchronization arising from a common extrahypothalamic input innervating bilateral magnocellular nuclei. First, two different retrograde tracers were injected into the right and left supraoptic nuclei of rats that were fixed 5-7 days later. Each tracer labelled numerous neurons in various brain regions ipsilateral or contralateral to the injection site, but colocalization of the two tracers within the same cell body could only be detected bilaterally in neurons in the ventromedial regions of the medulla oblongata. The axonal projections of these medullary neurons were then visualized by the unilateral microinjection of an anterograde tracer (BDA) within the ventromedial medulla oblongata. BDA-labelled axons afferent to the hypothalamus were found to branch towards both supraoptic nuclei through medial portions of the optic chiasma. Finally, in anaesthetized lactating rats, surgical lesions were placed medially...Continue Reading

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Citations

Feb 4, 2010·The Journal of Physiology·Ion R PopescuJeffrey G Tasker
May 26, 2012·Trends in Neurosciences·Donald W PfaffDonald Faber
May 25, 2010·Physiology & Behavior·Jan G VeeningHenk P Barendregt
May 8, 2013·Neuroscience and Biobehavioral Reviews·Jan G Veening, Berend Olivier
Jul 29, 2008·Progress in Brain Research·Glenn I Hatton, Yu-Feng Wang
Jan 13, 2018·Journal of Neuroendocrinology·Rachael A AugustineColin H Brown
May 15, 2020·Journal of Neuroendocrinology·Colin H BrownJavier E Stern

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