Synchronized release of bufadienolides in a stable Lutrol F127 based solid dispersion prepared with spray congealing

Drug Development and Industrial Pharmacy
Wenbao ZuoJianhong Yang

Abstract

The objective of this study was to design and prepare a novel solid dispersion using spray congealing to achieve fast and synchronous dissolution of bufalin, cinobufagin, and resibufogenin, three therapeutically complementary drugs. The solid dispersion was characterized with dissolution, X-ray diffractometry, and fourier transform infrared spectroscopy after preparation and storage for four weeks at different temperatures and relative humidity. It was found that all drugs were molecularly dispersed within matrix and had a significant enhancement (∼4-fold higher) of dissolution rate. Furthermore, synchronized release of different drugs from a single carrier was achieved due to the highly molecular dispersibility and the excellent solubilization properties of F127. In addition, the solid dispersion was physically stable for at least four weeks at controlled conditions. But for samples under stress conditions, the results showed that drug-rich phase was formed and storage temperature was the dominant factor in determining stability of the solid dispersion (SD). These findings highlight the fitness of spray congealing to co-deliver multiple drugs, which open new perspectives for the development of more advanced combination of mult...Continue Reading

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Citations

Jan 15, 2020·Drug Development and Industrial Pharmacy·Tingting FuJianhong Yang
Sep 29, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Serena BertoniNadia Passerini

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