Synchronous adrenocortical carcinoma and ovarian malignant mixed germ cell tumor: A case report and literature review

Medicine
Ying HeWei Wang

Abstract

Adrenocortical carcinoma (ACC) is an endocrine malignancy with poor prognosis, which commonly arises in a sporadic manner, but may also become a part of a familial syndrome. ACC rarely arises simultaneously with other malignant tumors. We report a case of a 29-year-old woman with ACC synchronously followed by an ovarian malignant mixed germ cell tumor. We describe the clinical, histopathological, and immunohistochemical findings and review the English literatures. So far, as we know, the patient presented here is the first case with synchronous malignant tumors of the adrenal gland and ovary. She was diagnosed with ovarian malignant mixed germ cell tumor with admixture of dysgerminoma and yolk sac tumor after ACC. The left adrenal tumor was resected laparoscopically on April 28, 2017. A total laparoscopic hysterectomy with unilateral (right) adnexectomy was performed on November 11, 2017. Up to now, illness condition has not progressed. Patient is free of disease at 3 months of follow-up. This is the first report in English literature about coexistence of ACC with ovarian malignant mixed germ cell tumor and the sixteenth case that presents a synchronous tumor associated with a sporadic ACC. This case reminds us that a comprehen...Continue Reading

References

Dec 17, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·T InoueO Yoshida
Sep 25, 2004·Pediatric Blood & Cancer·Catherine M Khayat, Donna L Johnston
Sep 16, 2010·Journal of Cancer·Marlon A Guerrero, Electron Kebebew
Jan 13, 2011·Familial Cancer·V Medina-AranaA M Fernández-Peralta
Mar 27, 2013·Journal of Pediatric Hematology/oncology·Xiao-Feng HeMeng Qiu
Jun 12, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Victoria M RaymondTobias Else
Nov 7, 2014·Journal of Pediatric Hematology/oncology·Rachael Courtney, Sarangarajan Ranganathan
Jul 21, 2015·Frontiers in Cell and Developmental Biology·Rossella Libé

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