Synchronous bilateral Wilms' tumor with liver metastasis.

BMC Urology
Senai Goitom SerekeFelix Bongomin

Abstract

Wilms' tumor (nephroblastoma) is mostly unilateral; however, bilateral Wilms' tumors are seen in about 5-8% of patients. This can be synchronous or metachronous. It is uncommon to get liver metastasis from bilateral Wilms' tumor. An 8-year-old male Ugandan presented with a history of abdominal swelling and flank pains for 1 year. There was no history of hematuria. Both ultrasound and computed tomography of the abdomen demonstrated multiple solid lesions in both kidneys and a huge solid mass in segments V, VI, VII and VIII of the liver. Histological examination of renal biopsy specimen was favorable for chemotherapeutic regimens. However, following a multidisciplinary tumor board consensus, a nephron-sparing surgery was deemed unsuitable, and he was managed conservatively with chemotherapy (adriamycin and vincristine) with a palliative intent. Metastatic bilateral Wilms' tumor has a particularly poor prognosis. There are no clear evidence-based guidelines for the management of this rare presentation. This patient benefited from early palliative care and symptom management.

References

Sep 14, 2000·The Urologic Clinics of North America·H L Neville, M L Ritchey
Feb 1, 2006·Expert Review of Anticancer Therapy·Filippo Spreafico, Franca Fossati Bellani
Mar 12, 2011·Annals of Surgery·Thomas E HamiltonRobert C Shamberger
Jul 14, 2012·Advances in Pediatrics·Andrew M Davidoff
Jul 10, 2014·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·A Adegboyega OlukayodeO Awosanya Gbolahan
Jan 31, 2015·Pediatric Surgery International·Kathleen Kieran, Andrew M Davidoff
Jan 28, 2017·Indian Journal of Surgical Oncology· Raghunath Bv Ramesh S
Jul 19, 2017·Expert Reviews in Molecular Medicine·Jocelyn CharltonKathy Pritchard-Jones
Nov 3, 2017·Journal of Global Oncology·Festus NjugunaSaskia Mostert
Dec 8, 2019·The Journal of Surgical Research·Megan E CunninghamBindi J Naik-Mathuria

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Military Medicine
D T Schamber, K E Van Buskirk
The Journal of Urology
L G GOLDBERG, A DIAZ
Indian Journal of Pediatrics
R V PatelM H Mehta
Revista do Hospital das Clínicas
S ArapJ G Freire
Archiv für Kinderheilkunde
I WOLFROM
© 2021 Meta ULC. All rights reserved