Synchronous Chemoradiation Nanovesicles by X-Ray Triggered Cascade of Drug Release

Angewandte Chemie
Zijian ZhouXiaoyuan Chen

Abstract

The approach of concurrent-to-synchronous chemoradiation has now been advanced by well-designed nanovesicles that permit X-ray irradiation-triggered instant drug release. The nanovesicles consist of Au nanoparticles tethered with irradiation labile linoleic acid hydroperoxide (LAHP) molecules and oxidation-responsive poly(propylene sulfide)-poly(ethylene glycol) (PPS-PEG) polymers, where DOX were loaded in the inner core of the vesicles (Au-LAHP-vDOX). Upon irradiation, the in situ formation of hydroxyl radicals from LAHP molecules triggers the internal oxidation of PPS from being hydrophobic to hydrophilic, leading to degradation of the vesicles and burst release of cargo drugs. In this manner, synchronous chemoradiation showed impressive anticancer efficacy both in vitro and in a subcutaneous mouse tumor model by one-dose injection and one-time irradiation.

References

Dec 3, 2003·The New England Journal of Medicine·Arlene A ForastiereJay Cooper
Mar 3, 2004·Nature Materials·Alessandro NapoliJeffrey A Hubbell
Aug 29, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Simona CerritelliJeffrey A Hubbell
Oct 31, 2009·The Lancet Oncology·Jeffrey S TobiasUNKNOWN UK Head and Neck Cancer Trialists' Group
Sep 10, 2011·Journal of the National Cancer Institute·Walter J CurranJames D Cox
Sep 6, 2012·Journal of the American Chemical Society·Caroline de Gracia LuxAdah Almutairi
May 8, 2013·Angewandte Chemie·Yanfeng ZhangJianjun Cheng
Jul 23, 2013·Nature·Natalia L Komarova, C Richard Boland
Sep 26, 2013·Nature Reviews. Cancer·Caitriona HolohanPatrick G Johnston
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Jun 2, 2014·Nature Medicine·Ekaterina Y Lukianova-HlebDmitri O Lapotko
Oct 8, 2014·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Dec 30, 2014·The New England Journal of Medicine·Deborah A ZarinJerry Sheehan
Jul 15, 2015·Theranostics·Paul RetifMuriel Barberi-Heyob
Feb 4, 2016·Nature Reviews. Drug Discovery·Rachel M Webster
Jul 5, 2016·Journal of the American Chemical Society·Jana HerzbergerHolger Frey
Nov 3, 2016·Nature Reviews. Clinical Oncology·Juanita S Lopez, Udai Banerji
Oct 11, 2016·Chemical Society Reviews·Zijian ZhouXiaoyuan Chen
Jan 21, 2017·Advanced Science·Gurusamy SaravanakumarWon Jong Kim
Jun 24, 2017·Advanced Materials·Guosheng SongZhuang Liu
Jun 24, 2017·Angewandte Chemie·Feng LiHuaping Xu
Oct 20, 2017·Chemical Reviews·Wenpei FanXiaoyuan Chen
Oct 28, 2017·Nature Reviews. Materials·Hongmin ChenXiaoyuan Chen

❮ Previous
Next ❯

Citations

May 21, 2019·Chemical Society Reviews·Xiaofeng ChenHuanghao Yang
Nov 24, 2020·Advanced Healthcare Materials·Morgan E LorkowskiEfstathios Karathanasis
Dec 22, 2020·Advanced Science·Sandhya ClementEwa M Goldys
Mar 16, 2021·Matter·Xu ZhangXiaoyuan Chen
Aug 10, 2021·International Journal of Pharmaceutics·Qing-Hua LanQing Yao
Sep 14, 2018·ACS Applied Materials & Interfaces·Mengqi SuTing Guo
Jan 13, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jieyao ChenYue Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.