Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor (GIST).

International Journal of Colorectal Disease
Marcovalerio MelisAlessandro Fichera

Abstract

Little is known about the synchronous occurrence of gastrointestinal stromal tumors (GISTs) and other gastrointestinal tumors. We present two cases of an invasive colon cancer with a synchronous small-bowel GIST; immunohistochemistry studies were performed to evaluate possible genetic similarities. This paper reports two cases of synchronous GISTs and colorectal cancer (CRC) with immunohistochemistry analysis of c-Kit expression. This paper is also a review of the existing literature on the association of GISTs and CRC and the role of c-Kit in CRC. In the last 2 years, we observed two patients with synchronous CRCs and GISTs of the small bowel. The GISTs were incidentally discovered during the work-up for CRCs and excised at the time of the colon resection. Immunohistochemistry study did not reveal an expression of c-Kit in CRCs. Clinical implications of the association between these two neoplasms are described in this paper. Synchronous CRC and GIST has been more frequently reported. Because of the limited number of cases, we cannot exclude an incidental relationship. The genetic pathways of tumorigenesis appear different for the two neoplasms. Further studies are needed to clarify a possible role of c-Kit in the development o...Continue Reading

References

Dec 1, 1987·Annals of Surgery·P C McGrathG A Parker
Sep 1, 1983·The American Journal of Surgical Pathology·M T Mazur, H B Clark
Jan 1, 1993·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·M ToyotaA Yachi
Jan 1, 1995·Annals of Surgical Oncology·K C ConlonM F Brennan
Jan 28, 1999·Langenbeck's Archives of Surgery·M HahnH K Schackert
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·D Linnekin
Oct 18, 2000·Annals of Surgical Oncology·I PidhoreckyJ F Gibbs
Nov 30, 2000·Surgical Oncology·F C EilberF R Eilber
Feb 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G BelloneU Rodeck
Nov 14, 2001·Lancet·A T van OosteromUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Nov 28, 2002·Clinical Colorectal Cancer·Jennifer ReedDomenico Coppola
Jan 17, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Annick D Van den Abbeele, Ramsey D Badawi
Sep 2, 2003·International Journal of Cancer. Journal International Du Cancer·Carlo Riccardo RossiMario Lise
Sep 6, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S StroobantsA van Oosterom
Apr 28, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W Y AuT W Shek
May 11, 2004·International Journal of Colorectal Disease·Innocenzo SammarcoRaffaele Geremia
Dec 23, 2004·Endocrine-related Cancer·Christian F SingerErnst Kubista
Jun 11, 2005·Journal of Gastroenterology and Hepatology·Arash NowainSumita Verma

❮ Previous
Next ❯

Citations

Dec 3, 2013·Indian Journal of Surgical Oncology·M R Sreevathsa
Aug 22, 2007·World Journal of Surgical Oncology·Papalambros EfstathiosGiannopoulos Athanasios
Nov 7, 2008·World Journal of Surgical Oncology·Gian Paolo SpinelliSilverio Tomao
Oct 16, 2009·Cases Journal·Ibrahim MasoodiImtiyaz A Wani
Dec 6, 2008·World Journal of Gastroenterology : WJG·Chien-Yuan HungWen-Hsiung Chang
Dec 30, 2006·Seminars in Diagnostic Pathology·Abbas AgaimyMarkku Miettinen
Aug 19, 2007·Journal of Gastroenterology·Łukasz LiszkaJoanna Huszno
Feb 26, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sonja E Steigen, Tor J Eide
Oct 23, 2010·Techniques in Coloproctology·A Amato
Oct 11, 2008·ANZ Journal of Surgery·Sri Vengadesh GopalElizabeth L C Salisbury
Jun 12, 2013·Journal of Gastrointestinal Cancer·Julio A Diaz-PerezAbhinay Reddy
Jan 14, 2009·Southern Medical Journal·Dimitrios A DimitroulopoulosAikaterini P Fotopoulou
Feb 22, 2012·Journal of Gastrointestinal Cancer·Jacopo GiulianiAntonio Frassoldati
Aug 23, 2019·World Journal of Gastroenterology : WJG·Johanna WaidhauserBruno Märkl
Apr 13, 2010·International Journal of Surgery·Sheila S FerreiraBernardo Garicochea

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.