Synchronous detection of T-cell clonality and FIP1L1-PDGFRA fusion gene in a hypereosinophilic syndrome

La Revue de médecine interne
C MartinaudP Brisou

Abstract

We report a 49-year-old man suffering from chronic hypereosinophilia whose biological tests revealed a gene rearrangement between FIP1L1 and PDGFRA as well as a T-cell clonality. After 1 year of therapy with imatinib mesylate (100 mg daily), the patient was clinically asymptomatic, the fusion transcript was undetectable using RTQ-PCR and no lymphoproliferative disorders occurred. This unique combination raises the question of the physiopathology of such a grey zone hypereosinophilia and their management.

References

Jul 11, 2000·British Journal of Haematology·F RoufosseE Cogan
Jan 15, 2003·Annual Review of Medicine·Florence RoufosseMichel Goldman
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Amy D KlionUNKNOWN The Hypereosinophilic Syndromes Working Group
Nov 30, 2006·Current Opinion in Hematology·Sarah Fletcher, Barbara Bain
Sep 18, 2007·Immunology and Allergy Clinics of North America·Hans-Uwe Simon, Jan Cools
Feb 10, 2009·La Revue de médecine interne·J-V MalfusonT de Revel
Sep 8, 2009·Haematologica·Grzegorz HelbigSlawomira Kyrcz-Krzemien
Nov 17, 2009·The Journal of Allergy and Clinical Immunology·Princess U OgboguAmy D Klion
Mar 23, 2010·La Revue de médecine interne·J-E KahnO Blétry

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