Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality

Journal of the National Cancer Institute
Michael S AnglesioDavid G Huntsman

Abstract

Many women with ovarian endometrioid carcinoma present with concurrent endometrial carcinoma. Organ-confined and low-grade synchronous endometrial and ovarian tumors (SEOs) clinically behave as independent primary tumors rather than a single advanced-stage carcinoma. We used 18 SEOs to investigate the ancestral relationship between the endometrial and ovarian components. Based on both targeted and exome sequencing, 17 of 18 patient cases of simultaneous cancer of the endometrium and ovary from our series showed evidence of a clonal relationship, ie, primary tumor and metastasis. Eleven patient cases fulfilled clinicopathological criteria that would lead to classification as independent endometrial and ovarian primary carcinomas, including being of FIGO stage T1a/1A, with organ-restricted growth and without surface involvement; 10 of 11 of these cases showed evidence of clonality. Our observations suggest that the disseminating cells amongst SEOs are restricted to physically accessible and microenvironment-compatible sites yet remain indolent, without the capacity for further dissemination.

References

Sep 19, 1998·Gynecologic Oncology·N TakeshimaK Hasumi
Mar 8, 2000·Archives of Pathology & Laboratory Medicine·S M Selvaggi
Jun 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·A HartmannR Knuechel
Dec 22, 2005·Journal of the National Cancer Institute·Svetlana VinokurovaMagnus von Knebel Doeberitz
Jan 24, 2007·American Journal of Obstetrics and Gynecology·Ali AyhanKunter Yuce
Sep 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susan J RamusSimon A Gayther
Dec 2, 2008·Otolaryngologic Clinics of North America·Mingzhao Xing
Oct 15, 2010·The New England Journal of Medicine·Kimberly C WiegandDavid G Huntsman
Oct 19, 2010·Nucleic Acids Research·Simon A ForbesP Andrew Futreal
Mar 8, 2011·The Journal of Pathology·Melissa K McConechyDavid G Huntsman
Mar 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David S P TanJorge S Reis-Filho
May 17, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Neeraj LalwaniNajla Fasih
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jun 2, 2012·The Journal of Pathology·Melissa K McConechyDavid G Huntsman
Mar 27, 2013·Human Molecular Genetics·David N ChurchIan P M Tomlinson
May 3, 2013·Nature·Cyriac KandothDouglas A Levine
Jun 15, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Melissa K McConechyDavid G Huntsman
Dec 5, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Florian HeitzAndreas du Bois
Jul 16, 2014·The American Journal of Surgical Pathology·Michael Herman ChuiBlaise A Clarke
Nov 26, 2014·Clinical Chemistry·Hongdo Do, Alexander Dobrovic
Feb 19, 2015·The Journal of Pathology·Michael S AnglesioDavid G Huntsman
Jun 23, 2015·The American Journal of Surgical Pathology·Robertson MackenzieMichael S Anglesio
Jul 15, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lien N HoangCheng-Han Lee
Jul 15, 2015·British Journal of Cancer·A TalhoukJ N McAlpine
Feb 3, 2016·Journal of the National Cancer Institute·Anne M SchultheisBritta Weigelt

❮ Previous
Next ❯

Citations

Feb 3, 2016·Journal of the National Cancer Institute·Anne M SchultheisBritta Weigelt
Nov 26, 2016·Nature Reviews. Cancer·Anthony N KarnezisDavid G Huntsman
May 11, 2017·The New England Journal of Medicine·Michael S AnglesioIe-Ming Shih
May 13, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Vandana JainSudhir Rawal
Sep 8, 2017·Case Reports in Oncology·Georgios-Marios MakrisCharalampos Chrelias
Mar 3, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lingyi YangWenfeng Cao
Sep 19, 2017·International Journal of Cancer. Journal International Du Cancer·Colin B BeggJorge S Reis-Filho
Dec 15, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Colin J R StewartBrigitte M Ronnett
Dec 15, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Naveena SinghEsther Oliva
May 12, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Georgia KarpathiouMichel Peoc'h
Jun 17, 2016·Cancer·Jessica N McAlpineHelen J Mackay
Sep 4, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kala VisvanathanMark R Somerfield
Feb 6, 2020·International Journal of Cancer. Journal International Du Cancer·Casper ReijnenJohanna M A Pijnenborg
Jan 23, 2018·Advances in Anatomic Pathology·W Glenn McCluggage
Jul 22, 2020·Obstetrics & Gynecology Science·Andreas ObermairMonika Janda
Sep 15, 2019·Archives of Gynecology and Obstetrics·Xiangbo ZhanJinghe Lang
Jul 18, 2018·International Journal of Molecular Sciences·Anna Myriam PerroneGiuseppe Gasparre
Jan 20, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Arnold-Jan KruseHans W Nijman
Nov 28, 2018·Journal of Gynecologic Oncology·Yutaka YoneokaTomoyasu Kato
Feb 3, 2016·Journal of the National Cancer Institute·Don S Dizon, Michael J Birrer
Aug 2, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pauline KrämerMichael S Anglesio
Jan 6, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nicole ConcinCarien L Creutzberg
Jan 8, 2021·American Journal of Obstetrics and Gynecology·Koji MatsuoJason D Wright
Dec 18, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lea A MoukarzelBritta Weigelt
Feb 20, 2021·Virchows Archiv : an International Journal of Pathology·Nicole ConcinXavier Matias-Guiu
Nov 6, 2018·Hematology/oncology Clinics of North America·Thing Rinda SoongChristopher P Crum
Mar 14, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicole ConcinCarien L Creutzberg
Mar 27, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Cindy Hsuan WengChyong-Huey Lai
Mar 27, 2021·Seminars in Cancer Biology·Khalid El BairiSaid Afqir
Nov 27, 2020·EJC Supplements : EJC : Official Journal of EORTC, European Organization for Research and Treatment of Cancer ... [et Al.]·Ignacio RomeroJosé Palacios
May 3, 2021·BMC Cancer·Wonkyo ShinSang-Soo Seo
May 5, 2021·Journal of Ovarian Research·Ling ZhouXiaohong Chang
Jul 17, 2021·Journal of Surgical Oncology·Paulina CybulskaMario M Leitao
Aug 11, 2021·Surgical Pathology Clinics·Zehra OrduluLauren L Ritterhouse

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
J KupryjanczykD W Yandell
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
M L PearlJ A Roberts
European Journal of Gynaecological Oncology
F MontoyaF J Rodriguez-Escudero
© 2021 Meta ULC. All rights reserved