Synchronous splenectomy and hepatectomy for patients with hepatocellular carcinoma and hypersplenism: A case-control study

World Journal of Gastroenterology : WJG
Xiao-Yun ZhangLi Jiang

Abstract

To investigate whether the use of synchronous hepatectomy and splenectomy (HS) is more effective than hepatectomy alone (HA) for patients with hepatocellular carcinoma (HCC) and hypersplenism. From January 2007 to March 2013, 84 consecutive patients with HCC and hypersplenism who underwent synchronous hepatectomy and splenectomy in our center were compared with 84 well-matched patients from a pool of 268 patients who underwent hepatectomy alone. The short-term and long-term outcomes of the two groups were analyzed and compared. The mean time to recurrence was 21.11±12.04 mo in the HS group and 11.23±8.73 mo in the HA group, and these values were significantly different (P=0.001). The 1-, 3-, 5-, and 7-year disease-free survival rates for the patients in the HS group and the HA group were 86.7%, 70.9%, 52.7%, and 45.9% and 88.1%, 59.4%, 43.3%, and 39.5%, respectively (P=0.008). Platelet and white blood cell counts in the HS group were significantly increased compared with the HA group one day, one week, one month and one year postoperatively (P<0.001). Splenectomy and micro-vascular invasion were significant independent prognostic factors for disease-free survival. Gender, tumor number, and recurrence were independent prognostic...Continue Reading

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Citations

Mar 10, 2016·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Guo-Qing JiangXue-Hao Wang
May 20, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xiaoyun ZhangJiayin Yang
May 12, 2017·British Journal of Haematology·Joji ShimonoKoichi Ohshima
Oct 23, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Youliang PeiWanguang Zhang
Jan 25, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Na HuangZongfang Li
Oct 8, 2016·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Dou-Sheng BaiSheng-Jie Jin
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Jul 10, 2019·Experimental and Therapeutic Medicine·Yusuke HirakawaKoji Okuda
Dec 5, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Youliang PeiWanguang Zhang

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