Synchronously Amplified Photoacoustic Image Recovery (SAPhIRe).

Photoacoustics
Aida A DemissieRobert M Dickson

Abstract

In molecular and cellular photoacoustic imaging with exogenous contrast agents, image contrast is plagued by background resulting from endogenous absorbers in tissue. By using optically modulatable nanoparticles, we develop ultra-sensitive photoacoustic imaging by rejecting endogenous background signals and drastically improving signal contrast through time-delayed pump-probe pulsed laser illumination. Gated by prior pump excitation, modulatable photoacoustic (mPA) signals are recovered from unmodulatable background through simple, real-time image processing to yield background-free photoacoustic signal recovery within tissue mimicking phantoms and from ex-vivo tissues. Inherently multimodal, the fluorescence and mPA sensitivity improvements demonstrate the promise of Synchronously Amplified Photoacoustic Image Recovery (SAPhIRe) for PA imaging in diagnosis and therapy.

Citations

May 13, 2021·The Journal of Physical Chemistry. B·Baijie PengRobert M Dickson

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Methods Mentioned

BETA
Fluorescence
fluorescence imaging

Software Mentioned

SAPhIRe

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