PMID: 11341480May 9, 2001Paper

Synchrony of rest tremor in multiple limbs in parkinson's disease: evidence for multiple oscillators

Journal of Neural Transmission
H Ben-PaziE S Simon

Abstract

Recent evidence points to involvement of central nervous system oscillators in Parkinson's disease (PD) rest tremor. It remains unknown whether one or multiple oscillators cause tremor in multiple limbs. Based on the prediction that multiple oscillators would cause low coherence even with similar average frequency, we studied 22 PD patients using accelerometers on multiple limbs. Records were digitized and spectral analysis was performed. Peak frequencies in the arms, legs, and chin were similar, indicating that biomechanical factors did not determine the frequency. Coherence between different axes of individual accelerometers and between different segments of the same limb was high. However, coherence between tremor in different limbs was low. There was no consistent pattern across patients of ipsi- vs. contralateral predominance of coherence. These data suggest that tremor in PD is generated by multiple oscillatory circuits, which operate on similar frequencies.

Citations

Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Hagai Bergman, Günther Deuschl
Jun 6, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Josep Valls-Solé, Francesc Valldeoriola
Jul 31, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B HellwigC H Lücking
May 4, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Blake K ScanlonSpiridon Papapetropoulos
Jul 28, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Florian AmtageBernhard Hellwig
May 10, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Adriana Galvan, Thomas Wichmann
Nov 3, 2007·Parkinsonism & Related Disorders·S MorrisonP Silburn
Dec 3, 2015·Journal of Neuroengineering and Rehabilitation·Xin HeNing Lan
Nov 7, 2006·Current Opinion in Neurobiology·Michal Rivlin-EtzionHagai Bergman
Aug 31, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Elan D LouisHoward F Andrews
Jul 11, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Plamen GatevThomas Wichmann
Feb 4, 2009·The European Journal of Neuroscience·Christiane ReckLars Timmermann
Oct 19, 2004·Neuroscience Letters·Hatice KumruEduardo Tolosa
Dec 14, 2011·IEEE Transactions on Bio-medical Engineering·Gaddi BlumrosenDana Porrat
Sep 28, 2013·Experimental Neurology·John-Stuart Brittain, Peter Brown
Dec 23, 2016·Brain : a Journal of Neurology·Hayriye CagnanPeter Brown
Oct 22, 2004·Journal of Neurophysiology·José M HurtadoConrad T E Pappas
May 9, 2019·Journal of Neurophysiology·Steven MorrisonKarl M Newell
Oct 24, 2013·Current Opinion in Neurology·Ashwini OswalVladimir Litvak
Aug 2, 2002·Current Opinion in Neurology·Kapil D Sethi
Dec 4, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B J WilkesD E Vaillancourt

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